The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer

Trial Information

The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer

OBJECTIVES:

- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.

- Determine if patient prognosis is dependent on the region of 8p AI.

- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
on 8p.

- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.

OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
studies.

PROJECTED ACCRUAL: Approximately 480 patients will be accrued for this study.