Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the pancreas
Locoregional and not amenable to surgery based on 1 or more of the following: Size of
pancreatic tumor greater than 5 cm Lymph nodes bulky, greater than 2 cm, but within
radiation port Vascular involvement or impingement of major vessels (e.g., superior
mesenteric artery, superior mesenteric vein, portal vein, hepatic artery) Involvement of
colon (head lesions) or involvement of adrenal, kidney, or colon (tail lesions) Patients
must be registered and begin treatment within 42 days of surgical staging No metastatic
disease or nodal disease outside of radiation port documented by CT scan or MRI and chest
x-ray

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
Not specified Hematopoietic: Granulocyte count at least 1,500/mm3 Platelet count at least
100,000/mm3 Hepatic: Albumin greater than 3 g/dL Bilirubin less than 2.0 mg/dL Renal:
Creatinine less than 2.0 mg/dL Calcium normal Other: No prior or concurrent malignancy
within the past 5 years except inactive nonmelanoma skin cancer, carcinoma in situ of the
cervix, or other curatively treated cancers Not pregnant or nursing Negative pregnancy
test Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: No prior biologic therapy for carcinoma of the
pancreas Chemotherapy: No prior chemotherapy for carcinoma of the pancreas No other
concurrent chemotherapy Endocrine therapy: No prior endocrine therapy for carcinoma of the
pancreas No concurrent hormone therapy (except for nondisease-related conditions)
Radiotherapy: No prior radiation therapy for carcinoma of the pancreas No prior abdominal
radiation therapy Surgery: See Disease Characteristics No prior surgery for carcinoma of
the pancreas