Treatment of Ovarian Carcinoma With DNP-Modified Autologous Tumor Vaccine

Inclusion Criteria

DISEASE CHARACTERISTICS: Surgically debulked stage III or IV ovarian epithelial cancer
Must be able to obtain adequate number of viable cells from excised tumor mass Must have
received 6 courses of combination chemotherapy comprised of either paclitaxel and
cisplatin OR paclitaxel and carboplatin Must be clinically tumor free following completion
of chemotherapy (i.e., no metastasis by physical examination and CT of the abdomen and
pelvis and serum CA-125 less than 35 IU/L) Not on a Phase III GOG protocol

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0 or 1 Hematopoietic:
Hematocrit at least 25% WBC at least 3,000/mm3 Hepatic: Not specified Renal: Not specified
Other: Not pregnant or nursing No active infections HIV negative Hepatitis B surface
antigen negative Hepatitis C antibody negative No active autoimmune disease No prior
invasive malignancy within the past 5 years except nonmelanomatous skin cancer, carcinoma
in situ of the cervix, or superficial bladder cancer

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease
Characteristics 4-12 weeks since prior chemotherapy Endocrine therapy: No concurrent
systemic corticosteroids Radiotherapy: At least 6 months since prior major field
radiotherapy Surgery: See Disease Characteristics