Pilot Study of Adjuvant Fractionated Stereotactic Radiotherapy Following Surgical Removal of Cerebral Metastases

Trial Information

Pilot Study of Adjuvant Fractionated Stereotactic Radiotherapy Following Surgical Removal of Cerebral Metastases

OBJECTIVES: I. Assess the safety and tolerability of focal stereotactic radiotherapy to the
surgical bed following excision of cerebral metastases, as an alternative to whole brain
irradiation. II. Measure the local relapse rate at the surgical site after surgery and
stereotactic radiotherapy in patients with cerebral metastases. III. Measure the regional
relapse rate, in the brain but away from the treated site, following treatment in these
patients.

OUTLINE: All patients undergo surgical removal of their cerebral metastases followed by
adjuvant fractionated stereotactic radiotherapy daily for 5 days. Patients are given up to 5
weeks following surgery to recover and reach the required performance status. Radiotherapy
must commence within 6 weeks of surgery. Patients are followed at 2 weeks after treatment,
monthly for 6 months, every 3 months for the next 18 months, every 6 months for the next
year, and then annually for years 3-5.

PROJECTED ACCRUAL: There will be 20-40 patients accrued into this study.