A Phase III Study of Surgical Resection and Chemotherapy (Paclitaxel and Carboplatin) With or Without Adjuvant Radiotherapy for Resected Stage IIIA Non-Small Cell Lung Cancer
OBJECTIVES: I. Compare the overall survival of surgically resected patients with limited
stage IIIA non-small cell lung cancer who are treated by postoperative chemotherapy with or
without adjuvant radiotherapy. II. Compare failure free survival of these patients. III.
Describe the patterns of local and distant recurrence in these patients. IV. Determine the
toxicities associated with chemotherapy with or without adjuvant radiotherapy in these
patients.
OUTLINE: This is a randomized, multicenter study. Four to eight weeks after surgery, all
patients receive paclitaxel IV over 3 hours followed by carboplatin IV over 1-2 hours on
days 1, 22, 43, and 64. Following completion of four courses of chemotherapy, patients are
randomized into one of two treatment arms. Arm I: Patients receive no further therapy. Arm
II: Patients receive radiotherapy 5 days a week for 5 weeks to the mediastinum, beginning
2.5 to 4 weeks after completion of chemotherapy. Patients are followed at least every 4
months for 2 years, then every 6 months thereafter.
PROJECTED ACCRUAL: A total of 480 patients will be accrued for this study over 2 years.
Interventional
Allocation: Randomized, Primary Purpose: Treatment
Leslie J. Kohman, MD
Study Chair
State University of New York - Upstate Medical University
United States: Federal Government
CDR0000066266
NCT00003317
May 1998
Name | Location |
---|---|
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
CCOP - Duluth | Duluth, Minnesota 55805 |
CCOP - Scottsdale Oncology Program | Scottsdale, Arizona 85259-5404 |
CCOP - Cedar Rapids Oncology Project | Cedar Rapids, Iowa 52403-1206 |
Siouxland Hematology-Oncology | Sioux City, Iowa 51101-1733 |
Quain & Ramstad Clinic, P.C. | Bismarck, North Dakota 58501 |
CCOP - Merit Care Hospital | Fargo, North Dakota 58122 |
Altru Health Systems | Grand Forks, North Dakota 58201 |
CCOP - Toledo Community Hospital Oncology Program | Toledo, Ohio 43623-3456 |
Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
CCOP - Sioux Community Cancer Consortium | Sioux Falls, South Dakota 57105-1080 |