A Phase II Trial of Preradiation Multiagent Chemotherapy for Adults With "Poor Risk" Medulloblastoma, PNET, and Disseminated Ependymoma
OBJECTIVES:
- Determine the complete and partial response rate of patients with adult
medulloblastoma, primitive neuroectodermal tumor, or disseminated ependymoma treated
with preradiation combination chemotherapy.
- Determine the progression free survival and overall survival of these adult patients
treated with combination chemotherapy followed by craniospinal radiation.
- Determine the toxic effects associated with this treatment in these patients.
OUTLINE: Patients receive cisplatin IV over 6 hours, etoposide IV, and vincristine IV over
1-2 minutes on day 1; etoposide IV and cyclophosphamide IV over 1-2 hours on days 2-3;
filgrastim (G-CSF) subcutaneously (SC) on days 4-13; and vincristine IV over 1-2 minutes on
day 15. Treatment repeats every 42 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity.
Within 4-6 weeks after the last chemotherapy course, patients undergo radiotherapy 5 days a
week for 6 to 7 weeks.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually for 5-10 years.
PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study within 3 years.
Interventional
Primary Purpose: Treatment
Paul L. Moots, MD
Study Chair
Vanderbilt-Ingram Cancer Center
United States: Food and Drug Administration
CDR0000066256
NCT00003309
July 1998
Name | Location |
---|---|
H. Lee Moffitt Cancer Center and Research Institute | Tampa, Florida 33612 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
CCOP - Kalamazoo | Kalamazoo, Michigan 49007-3731 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Medical College of Wisconsin Cancer Center | Milwaukee, Wisconsin 53226 |
CCOP - Cedar Rapids Oncology Project | Cedar Rapids, Iowa 52403-1206 |
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon, New Hampshire 03756-0002 |
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center | Nashville, Tennessee 37232-2516 |
Veterans Affairs Medical Center - Lakeside Chicago | Chicago, Illinois 60611 |
CCOP - Marshfield Clinic Research Foundation | Marshfield, Wisconsin 54449 |
Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |