Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed stage III or IV epithelial ovarian
cancer that is refractory to platinum therapy or has relapsed within 12 months after
platinum therapy Minimal residual disease by laparotomy Must have adequate number of
peripheral stem cells collected No intraabdominal, pelvic disease, or other disease
greater than 1 cm No brain metastasis

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0-2 Life expectancy:
At least 12 weeks Hematopoietic: WBC greater than 3,500/mm3 Platelet count greater than
100,000/mm3 Hepatic: Bilirubin less than 2 times the upper limit of normal (ULN) Serum
transaminases less than 2 times ULN Renal: Creatinine clearance greater than 60 mL/min
Cardiovascular: Cardiac ejection fraction at least 45% No active angina No uncontrolled
hypertension Pulmonary: FEV1, vital capacity, and diffusion capacity greater than 50% of
predicted Other: Not HIV positive No active hepatitis B or C infection Not pregnant No
concurrent malignancy except basal cell or squamous cell carcinoma of the skin No serious
medical conditions such as uncontrolled diabetes mellitus

PRIOR CONCURRENT THERAPY: Biologic therapy: No immunotherapy within the past 4 weeks No
concurrent immunotherapy Chemotherapy: No chemotherapy within the past 4 weeks No
mitomycin within the past 6 weeks No other concurrent chemotherapy No prior anthracycline
therapy greater than 200 mg/m2 Endocrine therapy: Not specified Radiotherapy: No
radiotherapy within the past 4 weeks No concurrent radiotherapy No prior radiotherapy to
the whole abdomen Surgery: Prior surgery allowed