Treatment of Metastatic Renal Cell Carcinoma and Melanoma With Subsequential High-Dose Subcutaneous Interferon Alfa-2b and High-Dose Bolus and Continuous Intravenous Interleukin-2

Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically proven metastatic renal cell carcinoma or melanoma
Measurable or evaluable disease No active brain metastases Previously treated CNS
metastases responding to therapy are eligible, but CNS cannot be the site of evaluable
disease

PATIENT CHARACTERISTICS: Age: 18 and over Performance Status: ECOG 0-2 Life Expectancy:
Not specified Hematopoietic: Hematocrit at least 25 WBC at least 3,000/mm3 Platelet count
at least 100,000/mm3 PT and PTT within normal limits Hepatic: Bilirubin less than 2.0
mg/dL Renal: Creatinine less than 2.0 mg/dL Cardiovascular: No myocardial infarction
within 6 months No medication for congestive heart failure or cardiac arrhythmias No
hypertension (unless blood pressure is stable off medication) Pulmonary: Must have
reasonable respiratory reserves and not require supplemental oxygen No dyspnea at rest
Oxygen saturation must be greater than 90% for patients with risk of respiratory symptoms
Other: Not HIV positive Not positive for hepatitis B antigen No chronic underlying
immunodeficiency No concurrent active infection requiring antibiotic therapy Not pregnant
or nursing No concurrent serious illness No family history of malignant hyperthermia No
hypersensitivity to interferon alfa-2b and interleukin-2

PRIOR CONCURRENT THERAPY: Biologic therapy: No prior interleukin-2 and interferon alfa-2b
in combination therapy Chemotherapy: No prior systemic chemotherapy within 4 weeks of
study and recovered Endocrine therapy: No concurrent corticosteroid therapy Radiotherapy:
No prior radiotherapy within 4 weeks of interleukin-2 therapy No prior stereotactic
radiosurgery or gamma knife therapy within 1 week of interleukin-2 therapy Surgery: No
prior organ allograft transplantation Must be recovered from prior surgery Other: No
concurrent cyclosporin therapy No concurrent treatment with other anticancer agents