Vinblastine and Methotrexate in Children With Desmoid Tumor (Aggressive Fibromatosis) Which is Recurrent or Not Amenable to Surgical Resection or Irradiation - A Pediatric Oncology Group Phase II Study
OBJECTIVES: I. Estimate the efficacy and toxicity of vinblastine and methotrexate for newly
diagnosed or recurrent desmoid tumors in children who are not good candidates for treatment
with surgery or radiation therapy.
OUTLINE: Patients receive vinblastine and methotrexate IV weekly for 26 weeks, then every 2
weeks for an additional 26 weeks. Treatment continues for a maximum of 1 year in the absence
of unacceptable toxicity or disease progression. Patients with a complete response receive
an additional 8 doses of chemotherapy. Patients are followed every 6 months for 4 years and
then annually thereafter.
PROJECTED ACCRUAL: A total of 13-25 patients will be accrued for this study.
Interventional
Primary Purpose: Treatment
Steve Skapek, MD
Study Chair
St. Jude Children's Research Hospital
United States: Federal Government
CDR0000065601
NCT00003019
August 1997
Name | Location |
---|---|
Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
University of Texas - MD Anderson Cancer Center | Houston, Texas 77030-4009 |
University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
Children's Hospital of Philadelphia | Philadelphia, Pennsylvania 19104 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
Jonsson Comprehensive Cancer Center, UCLA | Los Angeles, California 90095-1781 |
University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
Indiana University Cancer Center | Indianapolis, Indiana 46202-5265 |
University of Iowa Hospitals and Clinics | Iowa City, Iowa 52242 |
University of Minnesota Cancer Center | Minneapolis, Minnesota 55455 |
Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
Ireland Cancer Center | Cleveland, Ohio 44106-5065 |
UCSF Cancer Center and Cancer Research Institute | San Francisco, California 94115-0128 |
CCOP - Kalamazoo | Kalamazoo, Michigan 49007-3731 |
Vanderbilt Cancer Center | Nashville, Tennessee 37232-6838 |
CCOP - Merit Care Hospital | Fargo, North Dakota 58122 |
NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York, New York 10016 |
Huntsman Cancer Institute | Salt Lake City, Utah 84112 |
David Grant Medical Center | Travis Air Force Base, California 94535 |
University of Wisconsin Comprehensive Cancer Center | Madison, Wisconsin 53792 |
Herbert Irving Comprehensive Cancer Center | New York, New York 10032 |
Veterans Affairs Medical Center - Fargo | Fargo, North Dakota 58102 |
Cancer Institute of New Jersey | New Brunswick, New Jersey 08901 |
University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
Long Beach Memorial Medical Center | Long Beach, California 90806 |
Children's Hospital Los Angeles | Los Angeles, California 90027-0700 |
Children's Hospital of Orange County | Orange, California 92668 |
Children's Hospital of Denver | Denver, Colorado 80218 |
Children's National Medical Center | Washington, District of Columbia 20010-2970 |
Children's Mercy Hospital | Kansas City, Missouri 64108 |
Children's Hospital Medical Center - Cincinnati | Cincinnati, Ohio 45229-3039 |
Children's Hospital of Columbus | Columbus, Ohio 43205-2696 |
Doernbecher Children's Hospital | Portland, Oregon 97201-3098 |
Children's Hospital of Pittsburgh | Pittsburgh, Pennsylvania 15213 |
Children's Hospital and Regional Medical Center - Seattle | Seattle, Washington 98105 |