Androgen Receptor Mutations in Hormone Refractory Prostate Cancer
N/A
N/A
Male
Prostate Cancer
Trial Information
Androgen Receptor Mutations in Hormone Refractory Prostate Cancer
OBJECTIVES: I. Test the feasibility of obtaining bone marrow specimens in a cooperative
group setting. II. Determine the frequency of bone marrow invasion by prostate cancer cells
in patients with hormone refractory prostate cancer. III. Evaluate the frequency of androgen
receptor (AR) mutations in bone marrow samples in this patient population. IV. Evaluate the
association between AR mutations and clinical outcomes, including survival, and response to
therapy, such as antiandrogen withdrawal. V. Evaluate the impact of prior pelvic
radiotherapy on the ability to obtain informative tissue.
OUTLINE: Blood and a bone marrow biopsy are collected from each patient before the patient
begins treatment on CLB-9480 or CLB-9583. The specimens are analyzed for androgen receptor
mutations. Patients do not receive results of the genetic testing and the results do not
influence the type or duration of treatment.
PROJECTED ACCRUAL: A total of 243 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS: Histologically proven adenocarcinoma of the prostate that is
refractory to hormone therapy Eligible for any prostate cancer chemotherapy protocol, but
have not started treatment Patients who are eligible for anticancer therapy on Protocol
CLB-9480, CLB-9583, CLB-9680, or CLB-9780 are also eligible for this study if they have
not started treatment on those protocols
PATIENT CHARACTERISTICS: Age: Any age Performance status: CALGB 0-2 Life expectancy: See
Disease Characteristics Hematopoietic: See Disease Characteristics Hepatic: See Disease
Characteristics Renal: See Disease Characteristics
PRIOR CONCURRENT THERAPY: See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Principal Investigator
Mary-Ellen Taplin, MD
Investigator Role:
Study Chair
Investigator Affiliation:
University of Massachusetts, Worcester
Authority:
United States: Federal Government
Study ID:
CDR0000065329
NCT ID:
NCT00002924
Start Date:
January 1997
Completion Date:
Related Keywords:
- Prostate Cancer
- adenocarcinoma of the prostate
- recurrent prostate cancer
- Prostatic Neoplasms
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| Vincent T. Lombardi Cancer Research Center, Georgetown University | Washington, District of Columbia 20007 |
| Walter Reed Army Medical Center | Washington, District of Columbia 20307-5000 |
| University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
| University of Iowa Hospitals and Clinics | Iowa City, Iowa 52242 |
| University of Massachusetts Memorial Medical Center | Worcester, Massachusetts 01655 |
| University of Minnesota Cancer Center | Minneapolis, Minnesota 55455 |
| Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
| Duke Comprehensive Cancer Center | Durham, North Carolina 27710 |
| Comprehensive Cancer Center of Wake Forest University Baptist Medical Center | Winston-Salem, North Carolina 27157-1082 |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus, Ohio 43210 |
| Medical University of South Carolina | Charleston, South Carolina 29425-0721 |
| Rhode Island Hospital | Providence, Rhode Island 02903 |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas, Nevada 89106 |
| University of California San Diego Cancer Center | La Jolla, California 92093-0658 |
| UCSF Cancer Center and Cancer Research Institute | San Francisco, California 94115-0128 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
| Marlene & Stewart Greenebaum Cancer Center, University of Maryland | Baltimore, Maryland 21201 |
| Ellis Fischel Cancer Center - Columbia | Columbia, Missouri 65203 |
| Barnes-Jewish Hospital | Saint Louis, Missouri 63110 |
| Norris Cotton Cancer Center | Lebanon, New Hampshire 03756 |
| CCOP - North Shore University Hospital | Manhasset, New York 11030 |
| State University of New York - Upstate Medical University | Syracuse, New York 13210 |
| CCOP - Southeast Cancer Control Consortium | Winston-Salem, North Carolina 27104-4241 |
| University of Tennessee, Memphis Cancer Center | Memphis, Tennessee 38103 |
| MBCCOP - Massey Cancer Center | Richmond, Virginia 23298-0037 |
| Mount Sinai Medical Center, NY | New York, New York 10029 |
| New York Presbyterian Hospital - Cornell Campus | New York, New York 10021 |
| Veterans Affairs Medical Center - Birmingham | Birmingham, Alabama 35233 |
| Veterans Affairs Medical Center - White River Junction | White River Junction, Vermont 05009 |
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| St. Barnabas Medical Center | Livingston, New Jersey 07039 |
| North Shore University Hospital | Manhasset, New York 11030 |
| Veterans Affairs Medical Center - Chicago (Westside Hospital) | Chicago, Illinois 60612 |
| Veterans Affairs Medical Center - San Francisco | San Francisco, California 94121 |
| CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse, New York 13217 |
| Veterans Affairs Medical Center - Memphis | Memphis, Tennessee 38104 |
| Veterans Affairs Medical Center - Richmond | Richmond, Virginia 23249 |
| University of Illinois at Chicago Health Sciences Center | Chicago, Illinois 60612 |
| Veterans Affairs Medical Center - Togus | Togus, Maine 04330 |
| Veterans Affairs Medical Center - Minneapolis | Minneapolis, Minnesota 55417 |
| Veterans Affairs Medical Center - Columbia (Truman Memorial) | Columbia, Missouri 65201 |
| University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
| Veterans Affairs Medical Center - Buffalo | Buffalo, New York 14215 |
| Veterans Affairs Medical Center - Syracuse | Syracuse, New York 13210 |
| Veterans Affairs Medical Center - Durham | Durham, North Carolina 27705 |
| St. Joseph's Hospital and Medical Center | Paterson, New Jersey 07503 |
