Bone Marrow Transplantation for Chronic Lymphocytic Leukemia

Inclusion Criteria

DISEASE CHARACTERISTICS: Chronic lymphocytic leukemia (CLL) patients after initial relapse
who have achieved a complete or partial remission with fludarabine therapy or after
initial relapse or progression Prolymphocytic leukemia in first remission or after relapse
Patients 15-65 years old who lack an HLA-identical sibling are eligible for autologous BM
transplantation Patients 16-50 years old with an HLA identical or one antigen mismatched
related donor are eligible for allogeneic BM transplantation

PATIENT CHARACTERISTICS: Age: 15-65 (See Disease Characteristics) Performance status:
Zubrod no more than 2 Hematopoietic: Not specified Hepatic: Bilirubin no greater than 1.5
mg/dL Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: Cardiac ejection
fraction at least 50% Pulmonary: DLCO at least 50% of predicted Other: No severe
concomitant medical or psychiatric illnesses

PRIOR CONCURRENT THERAPY: No extensive prior radiotherapy which would prevent
administration of total body radiation Patients may also participate in study MDA-DM-92082
for retroviral gene marking of the autologous marrow and blood cells