PHASE II TRIAL OF CHEMOTHERAPY PLUS RADIOTHERAPY FOR MANAGEMENT OF PRIMARY CENTRAL NERVOUS SYSTEM NON-HODGKIN'S LYMPHOMA (PCNSL)
OBJECTIVES: I. Assess the response to CHOD (cyclophosphamide/doxorubicin/vincristine/
dexamethasone) and BVAM (carmustine/vincristine/cytarabine/methotrexate) plus whole-brain
radiotherapy in patients with primary central nervous system non-Hodgkin's lymphoma (PCNSL).
II. Assess the toxic effects associated with this treatment. III. Assess the survival of
patients with PCNSL receiving this treatment. IV. Investigate the frequency of systemic
involvement at follow-up. V. Identify factors that appear to be associated with outcome.
OUTLINE: The following acronyms are used: ARA-C Cytarabine, NSC-63878 BCNU Carmustine,
NSC-409962 BVAM BCNU/VCR/ARA-C/MTX CF Leucovorin calcium, NSC-3590 CHOD CTX/DOX/VCR/DM CTX
Cyclophosphamide, NSC-26271 DM Dexamethasone, NSC-34521 DOX Doxorubicin, NSC-123127 MTX
Methotrexate, NSC-740 VCR Vincristine, NSC-67574 WBRT Whole-Brain Radiotherapy 4-Drug
Combination Chemotherapy followed by 4-Drug Combination Chemotherapy followed by
Radiotherapy. CHOD; followed by BVAM; followed by WBRT using 4-6 MV equipment (10 MV or
greater allowed with proper documentation).
PROJECTED ACCRUAL: Up to 35 patients will be entered over approximately 4.5 years. The study
will close early if there is an unacceptable incidence of severe toxicity or treatment
failure.
Interventional
Primary Purpose: Treatment
Brian P. O'Neill, MD
Study Chair
Mayo Clinic
United States: Federal Government
CDR0000064319
NCT00002676
July 1995
Name | Location |
---|---|
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Colorado Cancer Research Program, Inc. | Denver, Colorado 80209-5031 |
CCOP - Illinois Oncology Research Association | Peoria, Illinois 61602 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
CCOP - Kalamazoo | Kalamazoo, Michigan 49007-3731 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
CCOP - Northern New Jersey | Hackensack, New Jersey 07601 |
CCOP - Duluth | Duluth, Minnesota 55805 |
CCOP - Scottsdale Oncology Program | Scottsdale, Arizona 85259-5404 |
CCOP - Cedar Rapids Oncology Project | Cedar Rapids, Iowa 52403-1206 |
Siouxland Hematology-Oncology | Sioux City, Iowa 51101-1733 |
CCOP - Ochsner | New Orleans, Louisiana 70121 |
Quain & Ramstad Clinic, P.C. | Bismarck, North Dakota 58501 |
Altru Health Systems | Grand Forks, North Dakota 58201 |
CCOP - Toledo Community Hospital Oncology Program | Toledo, Ohio 43623-3456 |
Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
CCOP - Sioux Community Cancer Consortium | Sioux Falls, South Dakota 57105-1080 |
CCOP - Columbus | Columbus, Ohio 43206 |