A Double-Blind Placebo Controlled Study To Determine the Optimal Immunopharmacological Dose Level of Isoprinosine in Immunodepressed Volunteers

Inclusion Criteria

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

- Opportunistic infections or Kaposi's sarcoma.

- Critical illness.

- History of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric
ulcer.

Concurrent Medication:

Excluded:

- Steroids.

- Cytotoxic immunosuppressive agents.

Concurrent Treatment:

Excluded:

- Radiotherapy.

The following are excluded:

- Opportunistic infections or Kaposi's sarcoma.

- Critically ill patients.

- Patients receiving steroids, cytotoxic immunosuppressive agents, and/or radiotherapy.

- Patients who have received any other immunotherapy.

- Patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction,
and severe gastric ulcer.

Prior Medication:

Excluded:

- Any other immunotherapy.

Patients who fall into the group which is at risk of developing cutaneous sarcoma and/or
opportunistic diseases but at present have no signs or symptoms of these diseases.