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Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits


N/A
N/A
N/A
Not Enrolling
Both
Acquired Immunodeficiency Syndrome, Alcoholism, HIV Infection, Neoplasm, Smoking

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Trial Information

Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits


We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and
other complex human characteristics. The main areas of interest are tobacco smoking, excess
alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The
subjects will be adult male and female probands who display one or more of the phenotypes of
interest together with their brothers, sisters and parents. Information on tobacco and
alcohol use, psychological and personality traits, sexual behavior, HIV status and
progression, and other characteristics with possible genetic components will be obtained
through structured interviews and questionnaires. DNA will be prepared from blood samples
and typed for a series of candidate genes chosen for function and for random polymorphic
markers. By correlating the genotypic and phenotypic information, we hope to identify
individual loci that interactively contribute to many different aspects of human health and
disease.

Inclusion Criteria


INCLUSION CRITERIA:

The basic requirement for entry in the study will be the presence of any individual smoker
who is willing to complete the evaluation process and donate a blood sample.

Additional siblings will be encouraged but not required to participate.

Probands will be recruited through smoking cessation programs at the National Naval
Medical Center.

Attendees at programs offered by the Health Promotions Department and the Military Family
Health Center will be invited to participate in this study.

EXCLUSION CRITERIA:

All subjects will be adults (greater than 18 years).

There will be no exclusions based on sex, ethnic group, or race.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

960061

NCT ID:

NCT00001500

Start Date:

April 1996

Completion Date:

July 2004

Related Keywords:

  • Acquired Immunodeficiency Syndrome
  • Alcoholism
  • HIV Infection
  • Neoplasm
  • Smoking
  • Smoking
  • Alcohol
  • HIV
  • AIDS
  • DNA Markers
  • Personality
  • Healthy Volunteers
  • Normal Volunteer
  • Acquired Immunodeficiency Syndrome
  • HIV Infections
  • Alcoholism
  • Neoplasms
  • Immunologic Deficiency Syndromes
  • Smoking

Name

Location
National Cancer Institute (NCI) Bethesda, Maryland  20892