Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma
This is a phase I/II study of interleukin-1, G-CSF and high dose ICE chemotherapy with
autologous bone marrow transplant in patients with relapsed breast, testicular and lymphoid
cancers. The initial goal of this study was to define the toxicity of interleukin-1
administered for 7 days prior to ICE chemotherapy. A total of 22 patients have been treated
with IL-1 and ICE and results showed a more rapid engraftment (4.5 days) with IL-1. A
second cohort of 18 patients also received G-CSF and engraftment was further shortened in
some subgroups. Overall, the median time to engraftment was 16 days with both IL-1 and
G-CSF. Accrual will continue to further define the toxicity and efficacy of this regimen.
Interventional
Endpoint Classification: Safety Study, Primary Purpose: Treatment
United States: Federal Government
910156
NCT00001270
June 1991
March 2000
Name | Location |
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National Cancer Institute (NCI) | Bethesda, Maryland 20892 |