Inclusion Criteria

High Risk Protocol: Patients with small non-cleaved (Burkitt or Burkitt-like) or diffuse
large cell lymphomas except those with:

a) Minimal extra-abdominal tumor as the sole site of disease and a serum LDH less than
1.5 times the upper limit of normal (NIH patients, less than 350 U/L) or except those
with b) completely resected small, localized abdominal mass (involved segmental lymph
nodes permitted) and a serum LDH level less than 1.5 times upper limit of normal (NIH
patients less than 350 U/L).

All patients with small non-cleaved (Burkitt or Burkitt-like) or diffuse large cell
lymphomas with a serum LDH level greater than 1.5 times the upper limit of normal (NIH
patients, greater than 350 U/L), regardless of the clinically documented extent of
disease.

All patients with small non-cleaved (Burkitt or Burkitt-like) or diffuse large cell
lymphomas with testicular involvement.

Low risk protocol: Patients with small non-cleaved (Burkitt or Burkitt-like) or diffuse
large cell lymphomas with a) minimal extra-abdominal disease as the sole site of disease
and a serum LDH less than 1.5 times the upper limit of normal (NIH patients, less than 350
U/L) or b) completely resected small, localized abdominal mass (involved segmental lymph
nodes permitted for gastrointestinal disease) and a serum LDH level less than 1.5 times
the upper limit of normal (NIH patients, less than 350 U/L).

No patients with lymphoblastic lymphomas, low grade or follicular lymphomas.

No patients with peripheral T cell lymphomas that do not fall into the category of
anaplastic large cell lymphoma.

No patients with a previously documented lymphoma or histological evidence of co-existing
lymphoma of other histology.

No patients who have been previously treated with chemotherapy or radiotherapy.

No patients with HIV infection.

No patients above the age of 60 years.

No patients with a history of inherited or non-HIV acquired immunodeficiency syndromes.