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Blood Sampling for Neurochemical and Genetic Testing


N/A
N/A
N/A
Not Enrolling
Both
Autonomic Nervous System Disease, Healthy, Hypertension, Pheochromocytoma

Thank you

Trial Information

Blood Sampling for Neurochemical and Genetic Testing


This project is to allow blood sampling from normal volunteers and patients with
dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving
catecholaminergic systems. The blood is used to establish normal values for plasma levels
of catechols and related neurochemicals; test for abnormal neurochemical patterns in
patients; and establish a "bank" of DNA samples from normal volunteers and from patients, to
be used in future studies about mutations or polymorphisms of catecholamine-related genes.

Inclusion Criteria


INCLUSION CRITERIA:

The subjects are healthy normal volunteers or patients with dysautonomia,
pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic
systems. Children of any age above 4 years may participate. In the case of minors,
consent is obtained from an adult who is legally responsible for the subject.

EXCLUSION CRITERIA:

Subjects in whom anatomic or technical factors preclude insertion of an arm intravenous
(i.v.) catheter are excluded. Normal volunteers taking any prescribed medication are
excluded. Normal volunteers who smoke cigarettes or consume alcohol daily are excluded.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

000008

NCT ID:

NCT00001147

Start Date:

October 1999

Completion Date:

March 2004

Related Keywords:

  • Autonomic Nervous System Disease
  • Healthy
  • Hypertension
  • Pheochromocytoma
  • Dopamine
  • Metanephrine
  • Norepinephrine
  • Epinephrine
  • Catecholamines
  • Tyrosine Hydroxylase
  • Monoamine Oxidase
  • Phenosulfotransferase
  • Sympathetic Nervous System
  • Normetanephrine
  • Autonomic Nervous System Diseases
  • Primary Dysautonomias
  • Hypertension
  • Nervous System Diseases
  • Pheochromocytoma

Name

Location
National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland  20892