A Prospective, Randomized, Comparative Study of the Safety and Efficacy of Clarithromycin Versus Rifabutin Versus the Combination of Clarithromycin Plus Rifabutin for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia or Disseminated MAC Disease in HIV-Infected Patients With CD4 Lymphocyte Counts <= 100 Cells/mm3

Inclusion Criteria

Inclusion Criteria

Concurrent Medication:

Recommended:

- PCP prophylaxis.

Allowed:

- GM-CSF or G-CSF.

- Erythropoietin.

- Therapies (including antiretrovirals) available through expanded access or treatment
IND programs.

- Other non-experimental therapies available by prescription.

- Antihistamines other than those specifically excluded.

Patients must have:

- Evidence or diagnosis of HIV infection or a history of an AIDS-defining condition by
CDC criteria.

- CD4 count <= 100 cells/mm3 within 90 days prior to study entry.

- Two baseline blood sample cultures negative for MAC within 30 days of study entry.

- No suspected disseminated MAC disease, in the opinion of the clinician.

NOTE:

- Patients with elevated GGT and/or triglycerides are allowed.

NOTE:

- Patients may co-enroll on ACTG 081/981/181, ACTG 175, ACTG 204, ACTG 193, ACTG 241,
or other acceptable protocols.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

- Known or suspected tuberculous infection or other non-tuberculous mycobacterial
infection requiring chemotherapy or chemoprophylaxis (with the exception of isoniazid
prophylaxis alone).

NOTE:

- Patients may enroll who successfully completed tuberculosis (TB) treatment and have
been off anti-TB drugs for more than 6 months with no symptoms of mycobacterial
infection.

- Active TB.

- Known hypersensitivity to study drugs.

- Malabsorption as defined by persistent diarrhea with more than 8 stools per day for >
6 weeks.

Concurrent Medication:

Excluded:

- Frequent (more than once per month), repeated, or continuous treatment courses of
quinolones, erythromycin, spiramycin, azithromycin, clarithromycin, or clindamycin.

- Concomitant terfenadine or astemizole.

Prior Medication:

Excluded:

- Prophylaxis with azithromycin, clarithromycin, or rifabutin for more than 4 months.