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Pharmacokinetics of Antituberculosis Agents in HIV-Infected Persons With Tuberculosis


N/A
13 Years
N/A
Not Enrolling
Both
HIV Infections, Tuberculosis

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Trial Information

Pharmacokinetics of Antituberculosis Agents in HIV-Infected Persons With Tuberculosis


Patients receive up to 8 weeks of two or more anti-tuberculosis drugs, of which at least two
are isoniazid, rifampin, pyrazinamide, or ethambutol. Blood specimens are collected at 2, 6,
and 10 hours after administration of study medication, once between Days 10 and 14 of a
phase of daily treatment and once while on an intermittent dose regimen (twice weekly or
three times weekly).

Inclusion Criteria


Inclusion Criteria

You may be eligible for this study if you:

- Are HIV-positive and have tuberculosis.

- Are 13 years of age or older.

- Have written, informed consent of parent or guardian if you are under 18 years of
age.

- Agree to practice abstinence or use barrier methods of birth control during the
study.

Exclusion Criteria

You will not be eligible for this study if you:

- Have any other disorder or condition which might cause study treatment to be
undesirable.

- Are pregnant.

Type of Study:

Interventional

Study Design:

Primary Purpose: Treatment

Principal Investigator

Keith Chirgwin

Investigator Role:

Study Chair

Authority:

United States: Federal Government

Study ID:

ACTG 309

NCT ID:

NCT00000950

Start Date:

Completion Date:

Related Keywords:

  • HIV Infections
  • Tuberculosis
  • Tuberculosis
  • Isoniazid
  • Pyrazinamide
  • Pyridoxine
  • Rifampin
  • AIDS-Related Opportunistic Infections
  • Drug Therapy, Combination
  • Ethambutol
  • Acquired Immunodeficiency Syndrome
  • Antitubercular Agents
  • HIV Infections
  • Acquired Immunodeficiency Syndrome
  • Tuberculosis

Name

Location
Harbor UCLA Med Ctr Torrance, California  90502
Tulane Univ School of Medicine New Orleans, Louisiana  70112
Mount Sinai Med Ctr New York, New York  10029
Univ of Southern California / LA County USC Med Ctr Los Angeles, California  900331079
Beth Israel Med Ctr New York, New York  10003
Univ of Pennsylvania at Philadelphia Philadelphia, Pennsylvania  19104
Univ of Hawaii Honolulu, Hawaii  96816
SUNY / Health Sciences Ctr at Brooklyn Brooklyn, New York  112032098
MetroHealth Med Ctr Cleveland, Ohio  441091998
Queens Med Ctr Honolulu, Hawaii  96816
Emory Univ Atlanta, Georgia  30308
St Vincent's Hosp / Mem Sloan-Kettering Cancer Ctr New York, New York  10021
University of Miami (Pediatric) Miami, Florida  33136