Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma

Inclusion Criteria

Inclusion Criteria

Concurrent Medication: Required:

- PCP prophylaxis with Bactrim, dapsone, or aerosolized pentamidine.

- Oral candidiasis prophylaxis with fluconazole, ketoconazole, or clotrimazole oral
troches.

- Antiretroviral agent available by therapy IND.

- MAI prophylaxis with rifabutin (in patients with CD4 counts < 100 cells/mm3).

Patients must have:

- HIV infection.

- Primary CNS lymphoma with NO systemic involvement.

Prior Medication:

Allowed:

- Prior corticosteroids.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

- Concomitant malignancy other than Kaposi's sarcoma, curatively treated carcinoma in
situ of the cervix, or squamous or basal cell carcinoma of the skin.

- Active uncontrolled infection.

- Renal failure, active nonmalignant duodenal ulcer, uncontrolled diabetes mellitus, or
other serious medical conditions that would preclude aggressive cytotoxic
chemotherapy administration.

- Active heart disease (congestive heart failure or heart block greater than first
degree on EKG).

Concurrent Medication:

Excluded:

- Any investigational agent other than antiretroviral agents available by therapy IND.

Patients with the following prior conditions are excluded:

- No prior malignancy other than Kaposi's sarcoma, curatively treated carcinoma in situ
of the cervix, or squamous cell or basal cell carcinoma of the skin.

- No new infectious complications within the past 2 weeks that require a change in
antibiotics.

- History of myocardial infarction within the past 3 months.

Prior Medication:

Excluded:

- Prior chemotherapy other than for Kaposi's sarcoma.