A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol
OBJECTIVES:
I. Collect human tumor tissue and other biological specimens (blood, serum, and bone marrow)
from patients with rhabdomyosarcoma or non-rhabdomyosarcoma soft tissue sarcoma diagnosed
and/or treated at a Children's Oncology Group (COG) member institution.
II. Provide a repository for storage of tissue and other biological specimens collected by
COG investigators from these patients.
III. Make these specimens available for approved projects by laboratory-based investigators.
IV. Collect clinical data on these patients who are not being treated on a COG therapeutic
study.
V. Define and compare the clinical features of patient subgroups with alveolar
rhabdomyosarcoma whose tumors carry the t(2;13), t(1;13) or neither translocation.
VI. Investigate the relationship between evidence of submicroscopic disease and response
rate (CR/PR), failure-free survival, and survival of patients with alveolar
rhabdomyosarcoma, as determined by positive or negative reverse transcriptase-polymerase
chain reaction (RT-PCR) assay for the t(2:13) and t(1:13) on peripheral blood and bone
marrow specimens obtained at diagnosis.
VII. Compare the clinical, cytogenetic, and molecular biologic features of patient subgroups
with anaplastic rhabdomyosarcoma and other subtypes of rhabdomyosarcoma.
OUTLINE:
Surgical tissue, bone marrow, and blood specimens are collected at diagnosis (initial or
relapse) and, if applicable, at the development of a second primary tumor. Specimens are
used for research purposes. A certificate of confidentiality protecting the identity of
research participants in this project has been issued by the National Cancer Institute.
Patients who are not enrolled on a Children's Oncology Group treatment trial are followed
every 6 months for at least 10 years or until disease progression or development of a second
malignancy.
Observational
Observational Model: Case-Only, Time Perspective: Prospective
Collection of human tumor tissue and other biological specimens (blood, serum, and bone marrow) from patients with rhabdomyosarcoma or non-rhabdomyosarcoma soft tissue sarcoma
Up to 10 years
No
Steve Skapek
Principal Investigator
Children's Oncology Group
United States: Institutional Review Board
D9902
NCT00919269
March 1999
Name | Location |
---|---|
Baylor College of Medicine | Houston, Texas 77030 |
Johns Hopkins University | Baltimore, Maryland 21205 |
Memorial Sloan Kettering Cancer Center | New York, New York 10021 |
Cleveland Clinic Foundation | Cleveland, Ohio 44195 |
Roswell Park Cancer Institute | Buffalo, New York 14263 |
Mayo Clinic | Rochester, Minnesota 55905 |
Children's Hospital of Philadelphia | Philadelphia, Pennsylvania 19104 |
University of Iowa Hospitals and Clinics | Iowa City, Iowa 52242 |
University of Mississippi Medical Center | Jackson, Mississippi 39216-4505 |
Washington University School of Medicine | Saint Louis, Missouri 63110 |
Medical University of South Carolina | Charleston, South Carolina 29425-0721 |
Tripler Army Medical Center | Honolulu, Hawaii 96859-5000 |
Hurley Medical Center | Flint, Michigan 48503 |
Rhode Island Hospital | Providence, Rhode Island 02903 |
Medical City Dallas Hospital | Dallas, Texas 75230 |
University of Texas Health Science Center at San Antonio | San Antonio, Texas 78284-7811 |
Midwest Children's Cancer Center | Milwaukee, Wisconsin 53226 |
Sinai Hospital of Baltimore | Baltimore, Maryland 21225 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
Geisinger Medical Center | Danville, Pennsylvania 17822-0001 |
Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
Loyola University Medical Center | Maywood, Illinois 60153 |
Massachusetts General Hospital Cancer Center | Boston, Massachusetts 02114 |
Morristown Memorial Hospital | Morristown, New Jersey 07962-1956 |
Marshfield Clinic | Marshfield, Wisconsin 54449 |
Loma Linda University Medical Center | Loma Linda, California 92354 |
Baptist Hospital of Miami | Miami, Florida 33176-2197 |
Newark Beth Israel Medical Center | Newark, New Jersey 07112 |
New York Medical College | Valhalla, New York 10595 |
Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
Cedars-Sinai Medical Center | Los Angeles, California 90048 |
University of Arkansas for Medical Sciences | Little Rock, Arkansas 72205 |
Brooke Army Medical Center | Fort Sam Houston, Texas 78234-6200 |
Madigan Army Medical Center | Tacoma, Washington 98431-5048 |
Eastern Maine Medical Center | Bangor, Maine 04401 |
William Beaumont Hospital | Royal Oak, Michigan 48073 |
University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
Hackensack University Medical Center | Hackensack, New Jersey 07601 |
Children's Hospital Los Angeles | Los Angeles, California 90027-0700 |
Children's National Medical Center | Washington, District of Columbia 20010-2970 |
Miami Children's Hospital | Miami, Florida 33155-4069 |
All Children's Hospital | St. Petersburg, Florida 33701 |
Advocate Hope Children's Hospital | Oak Lawn, Illinois 60453 |
Saint Jude Midwest Affiliate | Peoria, Illinois 61637 |
Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
Maine Children's Cancer Program | Scarborough, Maine 04074-9308 |
Carolinas Medical Center | Charlotte, North Carolina 28232-2861 |
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma 73104 |
Legacy Emanuel Hospital and Health Center | Portland, Oregon 97227 |
St. Jude Children's Research Hospital | Memphis, Tennessee 38105-2794 |
Driscoll Children's Hospital | Corpus Christi, Texas 78466 |
Scott and White Memorial Hospital | Temple, Texas 76508 |
Inova Fairfax Hospital | Falls Church, Virginia 22042-3300 |
Southern California Permanente Medical Group | Downey, California 90242 |
Children's Hospital Central California | Madera, California 93638-8762 |
Santa Barbara Cottage Hospital | Santa Barbara, California 93102 |
Kosair Children's Hospital | Louisville, Kentucky 40202-3830 |
Brooklyn Hospital Center | Brooklyn, New York 11201 |
Children's Hospital Medical Center of Akron | Akron, Ohio 44308 |
Covenant Children's Hospital | Lubbock, Texas 79410 |
University of Wisconsin Hospital and Clinics | Madison, Wisconsin 53792-0001 |
Overlook Hospital | Summit, New Jersey 07902-0220 |
Winthrop University Hospital | Mineola, New York 11501 |
Mount Sinai Medical Center | New York, New York 10029 |
Cincinnati Children's Hospital Medical Center | Cincinnati, Ohio 45229-3039 |
Methodist Children's Hospital of South Texas | San Antonio, Texas 78229-3993 |
Primary Children's Medical Center | Salt Lake City, Utah 84113-1100 |
Naval Medical Center - Portsmouth | Portsmouth, Virginia 23708-2197 |
Montefiore Medical Center | Bronx, New York 10467-2490 |
Saint Peter's University Hospital | New Brunswick, New Jersey 08901-1780 |
Rady Children's Hospital - San Diego | San Diego, California 92123-4282 |
Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis, Minnesota 55404 |
University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
Nationwide Children's Hospital | Columbus, Ohio 43205-2696 |
Children's Hospital of Pittsburgh of UPMC | Pittsburgh, Pennsylvania 15213 |
Dell Children's Medical Center of Central Texas | Austin, Texas 78723 |
Children's Hospital and Research Center at Oakland | Oakland, California 94609-1809 |
Mary Bridge Children's Hospital and Health Center | Tacoma, Washington 98415-0299 |
City of Hope Medical Center | Duarte, California 91010 |
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania 18017 |
Presbyterian Hospital | Charlotte, North Carolina 28233-3549 |
Lee Memorial Health System | Fort Myers, Florida 33902 |
University of Virginia | Charlottesville, Virginia 22908 |
University of Alabama at Birmingham | Birmingham, Alabama 35294-3300 |
Children's Hospital of Alabama | Birmingham, Alabama 35233 |
Connecticut Children's Medical Center | Hartford, Connecticut 06106 |
University of North Carolina | Chapel Hill, North Carolina 27599 |
Duke University Medical Center | Durham, North Carolina 27710 |
University of Florida | Gainesville, Florida 32610-0277 |
University of Rochester | Rochester, New York 14642 |
Nemours Children's Clinic - Pensacola | Pensacola, Florida 32504 |
Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids, Michigan 49503 |
Yale University | New Haven, Connecticut 06520 |
Wayne State University | Detroit, Michigan 48202 |
Mercy Children's Hospital | Toledo, Ohio 43608 |
Legacy Emanuel Children's Hospital | Portland, Oregon 97227 |
BI-LO Charities Children's Cancer Center | Greenville, South Carolina 29605 |
University of Arizona Health Sciences Center | Tucson, Arizona 85724 |
University of Massachusetts Medical School | Worcester, Massachusetts 01605 |
Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire 03756 |
University Of Vermont | Burlington,, Vermont 05403 |
Albany Medical Center | Albany, New York 12208 |
University of Texas Southwestern Medical Center | Dallas, Texas |
University of Kentucky | Lexington, Kentucky 40536-0098 |
UC Davis Comprehensive Cancer Center | Sacramento, California 95817 |
Oregon Health and Science University | Portland, Oregon 97201 |
Tulane University Health Sciences Center | New Orleans, Louisiana 70112 |
Virginia Commonwealth University | Richmond, Virginia |
David Geffen School of Medicine at UCLA | Los Angeles, California 90095 |
Florida Hospital | Orlando, Florida 32803 |
Memorial Health University Medical Center | Savannah, Georgia 31404 |
University of Chicago Comprehensive Cancer Center | Chicago, Illinois 60637-1470 |
M D Anderson Cancer Center | Houston, Texas 77030 |
Seattle Children's Hospital | Seattle, Washington 98105 |
Wake Forest University Health Sciences | Winston-Salem, North Carolina 27157 |
Childrens Memorial Hospital | Chicago, Illinois 60614 |
Kaiser Permanente-Oakland | Oakland, California 94611 |
Lombardi Comprehensive Cancer Center at Georgetown University | Washington, District of Columbia 20057 |
M D Anderson Cancer Center- Orlando | Orlando, Florida 32806 |
University of Hawaii | Honolulu, Hawaii 96813 |
Saint Luke's Mountain States Tumor Institute | Boise, Idaho 83712 |
Saint Vincent Hospital and Health Services | Indianapolis, Indiana 46260 |
Saint John Hospital and Medical Center | Detroit, Michigan 48236 |
Michigan State University - Breslin Cancer Center | East Lansing, Michigan 48824-1313 |
Kalamazoo Center for Medical Studies | Kalamazoo, Michigan 49008 |
Saint John's Mercy Medical Center | Saint Louis, Missouri 63141 |
Nevada Cancer Research Foundation CCOP | Las Vegas, Nevada 89106 |
Saint Barnabas Medical Center | Livingston, New Jersey 07039 |
New York University Langone Medical Center | New York, New York 10016 |
Columbia University Medical Center | New York, New York 10032 |
State University of New York Upstate Medical University | Syracuse, New York 13210 |
Mission Hospitals Inc | Asheville, North Carolina 28801 |
Natalie W Bryant Cancer Center | Tulsa, Oklahoma 74136 |
Saint Vincent Hospital | Green Bay, Wisconsin 54301 |
University of Maryland Greenebaum Cancer Center | Baltimore, Maryland 21201 |
University of Illinois | Chicago, Illinois 60612 |
Stony Brook University Medical Center | Stony Brook, New York 11794 |
Cook Children's Medical Center | Fort Worth, Texas 76104 |
Memorial Healthcare System - Joe DiMaggio Children's Hospital | Hollywood, Florida 33021 |
East Carolina University | Greenville, North Carolina 27858 |
West Virginia University Charleston | Charleston, West Virginia 25304 |
The Children's Medical Center of Dayton | Dayton, Ohio 45404 |
Advocate Lutheran General Hospital | Park Ridge, Illinois 60068 |
University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida 33136 |
University of Minnesota Medical Center-Fairview | Minneapolis, Minnesota 55455 |
Children's Oncology Group | Arcadia, California 91006-3776 |
C S Mott Children's Hospital | Ann Arbor, Michigan 48109 |
Southern Illinois University | Springfield, Illinois 62702 |
University Of Missouri-Columbia | Columbia, Missouri 65212 |
Walter Reed National Military Medical Center | Bethesda, Maryland 20889 |
Riley Hospital for Children | Indianapolis, Indiana 46202 |
Cardinal Glennon Children's Medical Center | St. Louis, Missouri 63104 |
UMDNJ - Robert Wood Johnson University Hospital | New Brunswick, New Jersey 08903 |
Phoenix Childrens Hospital | Phoenix, Arizona 85016 |
Miller Children's Hospital | Long Beach, California 90806 |
Childrens Hospital of Orange County | Orange, California 92868-3874 |
Alfred I duPont Hospital for Children | Wilmington, Delaware 19803 |
Nemours Children's Clinic - Jacksonville | Jacksonville, Florida 32207-8426 |
Nemours Childrens Clinic - Orlando | Orlando, Florida 32806 |
Saint Joseph Children's Hospital of Tampa | Tampa, Florida 33607 |
Children's Healthcare of Atlanta - Egleston | Atlanta, Georgia 30322 |
The Childrens Mercy Hospital | Kansas City, Missouri 64108 |
Rainbow Babies and Childrens Hospital | Cleveland, Ohio 44106 |
Penn State Hershey Children's Hospital | Hershey, Pennsylvania 17033 |
Palmetto Health Richland | Columbia, South Carolina 29203 |
East Tennessee Childrens Hospital | Knoxville, Tennessee 37916 |
Saint Mary's Hospital | West Palm Beach, Florida 33407 |
Children's Hospital and Medical Center of Omaha | Omaha, Nebraska 68114 |
Saint Joseph's Regional Medical Center | Paterson, New Jersey 07503 |
Texas Tech University Health Science Center-Amarillo | Amarillo, Texas 79106 |
Childrens Hospital-King's Daughters | Norfolk, Virginia 23507 |
Sanford Medical Center-Fargo | Fargo, North Dakota 58122 |
Children's Hospital Colorado | Aurora, Colorado 80045 |
Floating Hospital for Children at Tufts Medical Center | Boston, Massachusetts 02111 |
Lucile Packard Children's Hospital Stanford University | Palo Alto, California 94304 |
University of California San Francisco Medical Center-Parnassus | San Francisco, California 94143 |
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver, Colorado 80218 |
Raymond Blank Children's Hospital | Des Moines, Iowa 50309 |
Children's Hospital-Main Campus | New Orleans, Louisiana 70118 |
The Toledo Hospital/Toledo Children's Hospital | Toledo, Ohio 43606 |
Saint Christopher's Hospital for Children | Philadelphia, Pennsylvania 19134 |
Greenville Cancer Treatment Center | Greenville, South Carolina 29605 |
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota 57117-5134 |
T C Thompson Children's Hospital | Chattanooga, Tennessee 37403 |
Carilion Clinic Children's Hospital | Roanoke, Virginia 24014 |
Providence Sacred Heart Medical Center and Children's Hospital | Spokane, Washington 99204 |
Broward Health Medical Center | Fort Lauderdale, Florida 33316 |
The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park, New York 11040 |
Mattel Children's Hospital UCLA | Los Angeles, California 90095 |
Georgia Regents University | Augusta, Georgia 30912 |