A Randomized, Phase III Study of Standard Dosing Versus Longer Dosing Interval of Zoledronic Acid in Metastatic Cancer
OBJECTIVES:
Primary
- To compare the proportion of patients with metastatic breast cancer, metastatic
prostate cancer, or multiple myeloma involving bone who experience ≥ 1 skeletal-related
event during 2 years of treatment with zoledronic acid administered every 12 weeks vs
every 4 weeks.
Secondary
- To compare pain scores of these patients, as assessed by the Brief Pain Inventory
questionnaire.
- To compare the functional status (ECOG performance status) of these patients.
- To compare the incidence of osteonecrosis of the jaw in these patients.
- To compare the incidence of renal dysfunction in these patients.
- To compare the skeletal morbidity rate of these patients, defined as the number of
skeletal-related events per year.
OUTLINE: This is a multicenter study. Patients are stratified according to tumor type
(breast cancer vs prostate cancer vs multiple myeloma), baseline serum creatinine (≤ 1.4
mg/dL vs > 1.4 mg/dL), prior skeletal-related events (no vs yes), and prior oral
bisphosphate use (no vs yes). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 4
weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 12
weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
Patients complete the Brief Pain Inventory questionnaire at baseline and then every 4 weeks
for 2 years.
After completion of study treatment, patients are followed up every 4 weeks for 2 years from
registration.
Interventional
Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment
Proportion of patients with ≥ 1 skeletal-related event within 2 years after randomization
No
Andrew L. Himelstein, MD
Study Chair
Helen F. Graham Cancer Center at Christiana Hospital
United States: Federal Government
CDR0000637947
NCT00869206
March 2009
Name | Location |
---|---|
Roswell Park Cancer Institute | Buffalo, New York 14263 |
Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
CCOP - Upstate Carolina | Spartanburg, South Carolina 29303 |
CCOP - Wichita | Wichita, Kansas 67214-3882 |
Hurley Medical Center | Flint, Michigan 48503 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
CCOP - North Shore University Hospital | Manhasset, New York 11030 |
Veterans Affairs Medical Center - Atlanta (Decatur) | Decatur, Georgia 30033 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
CCOP - Iowa Oncology Research Association | Des Moines, Iowa 50309-1016 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
Aurora Presbyterian Hospital | Aurora, Colorado 80012 |
Boulder Community Hospital | Boulder, Colorado 80301-9019 |
Penrose Cancer Center at Penrose Hospital | Colorado Springs, Colorado 80933 |
CCOP - Colorado Cancer Research Program | Denver, Colorado 80224-2522 |
Porter Adventist Hospital | Denver, Colorado 80210 |
Presbyterian - St. Luke's Medical Center | Denver, Colorado 80218 |
St. Joseph Hospital | Denver, Colorado 80218 |
Rose Medical Center | Denver, Colorado 80220 |
Swedish Medical Center | Englewood, Colorado 80110 |
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction, Colorado 81502 |
Sky Ridge Medical Center | Lone Tree, Colorado 80124 |
Hope Cancer Care Center at Longmont United Hospital | Longmont, Colorado 80502 |
St. Mary - Corwin Regional Medical Center | Pueblo, Colorado 81004 |
North Suburban Medical Center | Thornton, Colorado 80229 |
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus | New Britain, Connecticut 06050 |
Joliet Oncology-Hematology Associates, Limited - West | Joliet, Illinois 60435 |
Saint Anthony Memorial Health Centers | Michigan City, Indiana 46360 |
Cedar Rapids Oncology Associates | Cedar Rapids, Iowa 52403 |
Mercy Medical Center - Sioux City | Sioux City, Iowa 51104 |
Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa 51101 |
St. Luke's Regional Medical Center | Sioux City, Iowa 51104 |
Baystate Regional Cancer Program at D'Amour Center for Cancer Care | Springfield, Massachusetts 01199 |
CCOP - Michigan Cancer Research Consortium | Ann Arbor, Michigan 48106 |
Saint Joseph Mercy Cancer Center | Ann Arbor, Michigan 48106-0995 |
Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn, Michigan 48123-2500 |
Genesys Hurley Cancer Institute | Flint, Michigan 48503 |
Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods, Michigan 48236 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Borgess Medical Center | Kalamazooaa, Michigan 49001 |
Sparrow Regional Cancer Center | Lansing, Michigan 48912-1811 |
St. John Macomb Hospital | Warren, Michigan 48093 |
MeritCare Bemidji | Bemidji, Minnesota 56601 |
Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota 55433 |
Duluth Clinic Cancer Center - Duluth | Duluth, Minnesota 55805-1983 |
CCOP - Duluth | Duluth, Minnesota 55805 |
Miller - Dwan Medical Center | Duluth, Minnesota 55805 |
Fairview Southdale Hospital | Edina, Minnesota 55435 |
Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota 55432 |
Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota 55109 |
Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota 55415 |
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota 55407 |
St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota 55379 |
Park Nicollet Cancer Center | St. Louis Park, Minnesota 55416 |
Regions Hospital Cancer Care Center | St. Paul, Minnesota 55101 |
United Hospital | St. Paul, Minnesota 55102 |
Ridgeview Medical Center | Waconia, Minnesota 55387 |
MeritCare Broadway | Fargo, North Dakota 58122 |
CCOP - MeritCare Hospital | Fargo, North Dakota 58122 |
Aultman Cancer Center at Aultman Hospital | Canton, Ohio 44710-1799 |
MetroHealth Cancer Care Center at MetroHealth Medical Center | Cleveland, Ohio 44109 |
St. Rita's Medical Center | Lima, Ohio 45801 |
Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa, Oklahoma 74136 |
Geisinger Medical Group - Scenery Park | State College, Pennsylvania 16801 |
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre, Pennsylvania 18711 |
Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls, South Dakota 57117-5039 |
Medical X-Ray Center, PC | Sioux Falls, South Dakota 57105 |
Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
Marshfield Clinic - Marshfield Center | Marshfield, Wisconsin 54449 |
Marshfield Clinic - Indianhead Center | Rice Lake, Wisconsin 54868 |
CCOP - Ochsner | New Orleans, Louisiana 70121 |
CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
Memorial Hospital of South Bend | South Bend, Indiana 46601 |
CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
CCOP - Columbus | Columbus, Ohio 43206 |
CCOP - Dayton | Kettering, Ohio 45429 |
Albert Einstein Cancer Center | Philadelphia, Pennsylvania 19141 |
Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
Virginia Mason Medical Center | Seattle, Washington 98111 |
Hinsdale, Illinois 60521 | |
CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
Saint Joseph Regional Medical Center | South Bend, Indiana 46617 |
Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia, Missouri 65203 |
CCOP - Columbia River Oncology Program | Portland, Oregon 97225 |
MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington 98405 |
MBCCOP - LSU Health Sciences Center | New Orleans, Louisiana 70112 |
Veterans Affairs Medical Center - Jackson | Jackson, Mississippi 39216 |
CCOP - Virginia Mason Research Center | Seattle, Washington 98101 |
CCOP - Northwest | Tacoma, Washington 98405-0986 |
Naval Medical Center - San Diego | San Diego, California 92134-3202 |
Veterans Affairs Medical Center - Pittsburgh | Pittsburgh, Pennsylvania 15240 |
Veterans Affairs Medical Center - Richmond | Richmond, Virginia 23249 |
Veterans Affairs Medical Center - Syracuse | Syracuse, New York 13210 |
Rebecca and John Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
Veterans Affairs Medical Center - San Diego | San Diego, California 92161 |
Louis A. Weiss Memorial Hospital | Chicago, Illinois 60640 |
West Suburban Center for Cancer Care | River Forest, Illinois 60305 |
Elmhurst Hospital Center | Elmhurst, New York 11373 |
Queens Cancer Center of Queens Hospital | Jamaica, New York 11432 |
John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines, Iowa 50309 |
St. Vincent Mercy Medical Center | Toledo, Ohio 43608 |
Thompson Cancer Survival Center | Knoxville, Tennessee 37916 |
Roger Williams Medical Center | Providence, Rhode Island 02908-4735 |
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | Baltimore, Maryland 21237 |
Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
St. John's Regional Health Center | Springfield, Missouri 65804 |
SUNY Downstate Medical Center | Brooklyn, New York 11203 |
McDowell Cancer Center at Akron General Medical Center | Akron, Ohio 44307 |
CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
Waukesha Memorial Hospital Regional Cancer Center | Waukesha, Wisconsin 53188 |
Long Island Jewish Medical Center | New Hyde Park, New York 11040 |
Broward General Medical Center Cancer Center | Ft. Lauderdale, Florida 33316 |
Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando, Florida 32803-1273 |
Winship Cancer Institute of Emory University | Atlanta, Georgia 30322 |
Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas 67214 |
Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
NYU Cancer Institute at New York University Medical Center | New York, New York 10016 |
Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
Medical University of Ohio Cancer Center | Toledo, Ohio 43614 |
Toledo Hospital | Toledo, Ohio 43606 |
Rhode Island Hospital Comprehensive Cancer Center | Providence, Rhode Island 02903 |
St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54307-3508 |
McCreery Cancer Center at Ottumwa Regional | Ottumwa, Iowa 52501 |
Green Bay Oncology, Limited - Escanaba | Escanaba, Michigan 49431 |
Dickinson County Healthcare System | Iron Mountain, Michigan 49801 |
CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York 13057 |
Chester County Hospital | West Chester, Pennsylvania 19380 |
St. Mary's Hospital Medical Center - Green Bay | Green Bay, Wisconsin 54303 |
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin 54301-3526 |
Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay, Wisconsin 54303 |
Bay Area Cancer Care Center at Bay Area Medical Center | Marinette, Wisconsin 54143 |
Green Bay Oncology, Limited - Oconto Falls | Oconto Falls, Wisconsin 54154 |
Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay, Wisconsin 54235 |
Sibley Memorial Hospital | Washington, District of Columbia 20016 |
North Colorado Medical Center | Greeley, Colorado 80631 |
McKee Medical Center | Loveland, Colorado 80539 |
William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan 48073 |
Hematology-Oncology Centers of the Northern Rockies - Billings | Billings, Montana 59101 |
St. Peter's Hospital | Helena, Montana 59601 |
Kalispell Regional Medical Center | Kalispell, Montana 59901 |
Glacier Oncology, PLLC | Kalispell, Montana 59901 |
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula, Montana 59802 |
Montana Cancer Specialists at Montana Cancer Center | Missoula, Montana 59802 |
Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina 27534 |
Adena Regional Medical Center | Chillicothe, Ohio 54601 |
Doctors Hospital at Ohio Health | Columbus, Ohio 43228 |
Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
Grady Memorial Hospital | Delaware, Ohio 43015 |
Fairfield Medical Center | Lancaster, Ohio 43130 |
Strecker Cancer Center at Marietta Memorial Hospital | Marietta, Ohio 45750 |
Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark, Ohio 43055 |
Community Hospital of Springfield and Clark County | Springfield, Ohio 45505 |
Genesis - Good Samaritan Hospital | Zanesville, Ohio 43701 |
Veterans Affairs Medical Center - Hines | Hines, Illinois 60141 |
UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha, Nebraska 68198-7680 |
New York Weill Cornell Cancer Center at Cornell University | New York, New York 10021 |
Zimmer Cancer Center at New Hanover Regional Medical Center | Wilmington, North Carolina 28402-9025 |
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | Washington, District of Columbia 20007 |
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise, Idaho 83712-6297 |
University of Illinois Cancer Center | Chicago, Illinois 60612-7243 |
CancerCare of Maine at Eastern Maine Medical Center | Bangor, Maine 04401 |
Keesler Air Force Base Medical Center | Keesler AFB, Mississippi 39534-2511 |
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | St. Louis, Missouri 63110 |
CCOP - Nevada Cancer Research Foundation | Las Vegas, Nevada 89109-2306 |
University of New Mexico Cancer Center | Albuquerque, New Mexico 87131-5636 |
Don Monti Comprehensive Cancer Center at North Shore University Hospital | Manhasset, New York 11030 |
Geisinger Cancer Institute at Geisinger Health | Danville, Pennsylvania 17822-0001 |
Virginia Commonwealth University Massey Cancer Center | Richmond, Virginia 23298-0037 |
Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin 54601 |
Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois 62526 |
Leonard C. Ferguson Cancer Center | Freeport, Illinois 61032 |
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
Elkhart General Hospital | Elkhart, Indiana 46515 |
Howard Community Hospital | Kokomo, Indiana 46904 |
Lakeland Regional Cancer Care Center - St. Joseph | St. Joseph, Michigan 49085 |
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton, New Jersey 08053 |
Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees, New Jersey 08043 |
Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown, Pennsylvania 18105 |
Front Range Cancer Specialists | Fort Collins, Colorado 80528 |
Veterans Affairs Medical Center - Chicago Westside Hospital | Chicago, Illinois 60612 |
University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
Joan Karnell Cancer Center at Pennsylvania Hospital | Philadelphia, Pennsylvania 19107 |
Jennersville Regional Hospital | West Grove, Pennsylvania 19390-9499 |
All Saints Cancer Center at Wheaton Franciscan Healthcare | Racine, Wisconsin 53405 |
North Bay Cancer Center | Fairfield, California 94533 |
Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
Poudre Valley Hospital | Fort Collins, Colorado 80524 |
Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter, Florida 33458 |
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise, Idaho 83706 |
Hematology Oncology Consultants - Naperville | Naperville, Illinois 60540 |
St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove, Indiana 46107 |
Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana 46350 |
Bettendorf, Iowa 52722 | |
St. Luke's Hospital | Cedar Rapids, Iowa 52402 |
Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa 52403 |
Genesis Regional Cancer Center at Genesis Medical Center | Davenport, Iowa 52803 |
John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines, Iowa 50316-2301 |
Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines, Iowa 50309 |
Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines, Iowa 50314 |
Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines, Iowa 50314 |
Medical Oncology and Hematology Associates - West Des Moines | West Des Moines, Iowa 50266 |
Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas 67801 |
Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge, Louisiana 70809 |
Medical Center of Louisiana - New Orleans | New Orleans, Louisiana 70112 |
Sturdy Memorial Hospital | Attleboro, Massachusetts 02703 |
Hickman Cancer Center at Bixby Medical Center | Adrian, Michigan 49221 |
Upper Michigan Cancer Center at Marquette General Hospital | Marquette, Michigan 49855 |
Community Cancer Center of Monroe | Monroe, Michigan 48162 |
Alexandria, Minnesota 56308 | |
St. Joseph's Medical Center | Brainerd, Minnesota 56401 |
Coborn Cancer Center | Saint Cloud, Minnesota 56303 |
CentraCare Clinic - River Campus | St. Cloud, Minnesota 56303 |
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | Grand Island, Nebraska 68803 |
Immanuel Medical Center | Omaha, Nebraska 68122 |
Creighton University Medical Center | Omaha, Nebraska 68131-2197 |
Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees, New Jersey 08043 |
Charles R. Wood Cancer Center at Glens Falls Hospital | Glens Falls, New York 12801 |
Iredell Memorial Hospital | Statesville, North Carolina 28677 |
Forsyth Regional Cancer Center at Forsyth Medical Center | Winston-Salem, North Carolina 27103 |
Bismarck Cancer Center | Bismarck, North Dakota 58501 |
Wood County Oncology Center | Bowling Green, Ohio 43402 |
Samaritan North Cancer Care Center | Dayton, Ohio 45415 |
Grandview Hospital | Dayton, Ohio 45405 |
David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
Good Samaritan Hospital | Dayton, Ohio 45406 |
Blanchard Valley Medical Associates | Findlay, Ohio 45840 |
Charles F. Kettering Memorial Hospital | Kettering, Ohio 45429 |
Lima Memorial Hospital | Lima, Ohio 45804 |
Northwest Ohio Oncology Center | Maumee, Ohio 43537 |
Middletown Regional Hospital | Middletown, Ohio 45044 |
Toledo Clinic - Oregon | Oregon, Ohio 43616 |
St. Charles Mercy Hospital | Oregon, Ohio 43616 |
North Coast Cancer Care, Incorporated | Sandusky, Ohio 44870 |
Mercy Hospital of Tiffin | Tiffin, Ohio 44883 |
Toledo Clinic, Incorporated - Main Clinic | Toledo, Ohio 43623 |
UVMC Cancer Care Center at Upper Valley Medical Center | Troy, Ohio 45373-1300 |
Fulton County Health Center | Wauseon, Ohio 43567 |
Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia, Ohio 45385 |
LaFortune Cancer Center at St. John Medical Center | Tulsa, Oklahoma 74104 |
Providence Milwaukie Hospital | Milwaukie, Oregon 97222 |
Kaiser Permanente Health Care - Portland | Portland, Oregon 97232 |
Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon 97213-2967 |
Providence St. Vincent Medical Center | Portland, Oregon 97225 |
Bryn Mawr Hospital | Bryn Mawr, Pennsylvania 19010 |
Delaware County Regional Cancer Center at Delaware County Memorial Hospital | Drexel Hill, Pennsylvania 19026 |
St. Mary Regional Cancer Center | Langhorne, Pennsylvania 19047 |
Lankenau Cancer Center at Lankenau Hospital | Wynnewood, Pennsylvania 19096 |
Southwest Washington Medical Center Cancer Center | Vancouver, Washington 98668 |
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima, Washington 98902 |
Holy Family Memorial Medical Center Cancer Care Center | Manitowoc, Wisconsin 54221-1450 |
Welch Cancer Center at Sheridan Memorial Hospital | Sheridan, Wyoming 82801 |
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital | Fairbanks, Alaska 99701 |
St. Anthony Central Hospital | Denver, Colorado 80204-1335 |
Exempla Lutheran Medical Center | Wheat Ridge, Colorado 80033 |
St. Francis Hospital | Federal Way, Washington 98003 |
Cascade Cancer Center at Evergreen Hospital Medical Center | Kirkland, Washington 98034-3013 |
St. Clare Hospital | Lakewood, Washington 98499-0998 |
Providence St. Peter Hospital Regional Cancer Center | Olympia, Washington 98506 |
Good Samaritan Cancer Center | Puyallup, Washington 98371 |
Allenmore Hospital | Tacoma, Washington 98411-0414 |
Lancaster General Hospital | Lancaster, Pennsylvania 17604-3555 |
Leavey Cancer Center at Northridge Hospital Medical Center | Northridge, California 91325 |
Highland General Hospital | Oakland, California 94602 |
Palo Alto Medical Foundation | Palo Alto, California 94301 |
Middlesex Hospital Cancer Center | Middletown, Connecticut 06457 |
Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City, Iowa 50401 |
Regional Cancer Center at Singing River Hospital | Pascagoula, Mississippi 39581 |
Saint Luke's Hospital | Chesterfield, Missouri 63017 |
Missouri Baptist Cancer Center | St. Louis, Missouri 63131 |
Cancer Resource Center - Lincoln | Lincoln, Nebraska 68510 |
Altru Cancer Center at Altru Hospital | Grand Forks, North Dakota 58201 |
Midelfort Clinic - Luther | Eau Claire, Wisconsin 54702 |
Tunnell Cancer Center at Beebe Medical Center | Lewes, Delaware 19958 |
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah, Georgia 31405 |
Evanston Hospital | Evanston, Illinois 60201-1781 |
Michiana Hematology-Oncology, PC - Elkhart | Elkhart, Indiana 46514 |
Elkhart Clinic, LLC | Elkhart, Indiana 46514-2098 |
Michiana Hematology Oncology PC - La Porte | La Porte, Indiana 46350 |
Michiana Hematology-Oncology, PC - South Bend | Mishawaka, Indiana 46545-1470 |
Michiana Hematology Oncology PC - Plymouth | Plymouth, Indiana 46563 |
Reid Hospital & Health Care Services | Richmond, Indiana 47374 |
McFarland Clinic, PC | Ames, Iowa 50010 |
Covenant Cancer Treatment Center | Waterloo, Iowa 50702 |
Cancer Center of Kansas, PA - Chanute | Chanute, Kansas 66720 |
Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas 67042 |
Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
Cancer Center of Kansas, PA - Kingman | Kingman, Kansas 67068 |
Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
Cancer Center of Kansas, PA - Liberal | Liberal, Kansas 67905 |
Cancer Center of Kansas, PA - Newton | Newton, Kansas 67114 |
Menorah Medical Center | Overland Park, Kansas 66209 |
Saint Luke's Hospital - South | Overland Park, Kansas 66213 |
Cancer Center of Kansas, PA - Parsons | Parsons, Kansas 67357 |
Cancer Center of Kansas, PA - Pratt | Pratt, Kansas 67124 |
Cancer Center of Kansas, PA - Salina | Salina, Kansas 67401 |
Cotton-O'Neil Cancer Center | Topeka, Kansas 66606 |
Cancer Center of Kansas, PA - Wellington | Wellington, Kansas 67152 |
Cancer Center of Kansas, PA - Wichita | Wichita, Kansas 67214 |
Associates in Womens Health, PA - North Review | Wichita, Kansas 67208 |
Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas 67208 |
Cancer Center of Kansas, PA - Winfield | Winfield, Kansas 67156 |
Ochsner Health Center - Bluebonnet | Baton Rouge, Louisiana 70809 |
Foote Memorial Hospital | Jackson, Michigan 49201 |
St. Mary Mercy Hospital | Livonia, Michigan 48154 |
Mercy Memorial Hospital - Monroe | Monroe, Michigan 48162 |
Michiana Hematology Oncology PC - Niles | Niles, Michigan 49120 |
St. Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
Mercy Regional Cancer Center at Mercy Hospital | Port Huron, Michigan 48060 |
Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw, Michigan 48601 |
Lakeside Cancer Specialists, PLLC | Saint Joseph, Michigan 49085 |
Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota 56201 |
Heartland Hematology Oncology Associates, Incorporated | Kansas City, Missouri 64118 |
North Kansas City Hospital | Kansas City, Missouri 64116 |
Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City, Missouri 64111 |
Research Medical Center | Kansas City, Missouri 64132 |
Saint Luke's East - Lee's Summit | Lee's Summit, Missouri 64086 |
Heartland Regional Medical Center | Saint Joseph, Missouri 64506 |
Saint Joseph Oncology, Incorporated | Saint Joseph, Missouri 64507 |
Billings Clinic - Downtown | Billings, Montana 59107-7000 |
Bozeman Deaconess Cancer Center | Bozeman, Montana 59715 |
St. James Healthcare Cancer Care | Butte, Montana 59701 |
Great Falls Clinic - Main Facility | Great Falls, Montana 59405 |
Sletten Cancer Institute at Benefis Healthcare | Great Falls, Montana 59405 |
Northern Montana Hospital | Havre, Montana 59501 |
Kalispell Medical Oncology at KRMC | Kalispell, Montana 59901 |
Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha, Nebraska 68124 |
Monter Cancer Center of the North Shore-LIJ Health System | Lake Success, New York 11042 |
Leo W. Jenkins Cancer Center at ECU Medical School | Greenville, North Carolina 27834 |
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | Columbus, Ohio 43210-1240 |
Grant Medical Center Cancer Care | Columbus, Ohio 43215 |
Hematology Oncology Center | Elyria, Ohio 44035 |
Community Cancer Center | Elyria, Ohio 44035 |
Wayne Hospital | Greenville, Ohio 45331 |
Knox Community Hospital | Mount Vernon, Ohio 43050 |
Fisher-Titus Medical Center | Norwalk, Ohio 44857 |
Flower Hospital Cancer Center | Sylvania, Ohio 43560 |
St. Anne Mercy Hospital | Toledo, Ohio 43623 |
Mount Carmel St. Ann's Cancer Center | Westerville, Ohio 43081 |
Salem Hospital Regional Cancer Care Services | Salem, Oregon 97309-5014 |
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania 18017 |
Geisinger Hazleton Cancer Center | Hazleton, Pennsylvania 18201 |
Hematology and Oncology Associates of Northeastern Pennsylvania | Scranton, Pennsylvania 18510 |
Fredericksburg Oncology, Incorporated | Fredericksburg, Virginia 22401 |
Providence Centralia Hospital | Centralia, Washington 98531-9027 |
Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington 98405-3004 |
Marshfield Clinic - Chippewa Center | Chippewa Falls, Wisconsin 54729 |
Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin 54701 |
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay, Wisconsin 54311 |
Vince Lombardi Cancer Clinic - Marinette | Marinette, Wisconsin 54143 |
Marshfield Clinic - Lakeland Center | Minocqua, Wisconsin 54548 |
Ministry Medical Group at Saint Mary's Hospital | Rhinelander, Wisconsin 54501 |
Vince Lombardi Cancer Clinic - Sheboygan | Sheboygan, Wisconsin 53081 |
Marshfield Clinic at Saint Michael's Hospital | Stevens Point, Wisconsin 54481 |
Aurora Medical Center | Summit, Wisconsin 53066 |
Vince Lombardi Cancer Clinic - Two Rivers | Two Rivers, Wisconsin 54241 |
Oncology Alliance, SC - Milwaukee - West | Wauwatosa, Wisconsin 53226 |
Marshfield Clinic - Weston Center | Weston, Wisconsin 54476 |
Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids, Wisconsin 54494 |
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst, North Carolina 28374 |
Mid Dakota Clinic, PC | Bismarck, North Dakota 58501 |
Regional Cancer Center at Memorial Medical Center | Springfield, Illinois 62781-0001 |
John H. Stroger, Jr. Hospital of Cook County | Chicago, Illinois 60612-9985 |
Lincoln Medical and Mental Health Center | Bronx, New York 10451 |
Genesys Regional Medical Center | Grand Blanc, Michigan 48439-8066 |
Phoebe Cancer Center at Phoebe Putney Memorial Hospital | Albany, Georgia 31702 |
Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney, Nebraska 68848-1990 |
Pardee Memorial Hospital | Hendersonville, North Carolina 28791 |
Rutherford Hospital | Rutherfordton, North Carolina 28139 |
Three Rivers Community Hospital | Grants Pass, Oregon 97527 |
Dubs Cancer Center at Rogue Valley Medical Center | Medford, Oregon 97504 |
Easton Regional Cancer Center at Easton Hospital | Easton, Pennsylvania 18042 |
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg, South Carolina 29303 |
Martha Jefferson Hospital Cancer Care Center | Charlottesville, Virginia 22901 |
Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin 53066 |
Harold Alfond Center for Cancer Care | Augusta, Maine 04330 |
Union Hospital of Cecil County | Elkton MD, Maryland 21921 |
Kinston Medical Specialists | Kinston, North Carolina 28501 |
Miriam Hospital | Providence, Rhode Island 02906 |
Manchester Memorial Hospital | Manchester, Connecticut 06040-4188 |
Jordan Hospital Club Cancer Center | Plymouth, Massachusetts 02360 |
Phelps County Regional Medical Center | Rolla, Missouri 65401 |
McLeod Regional Medical Center | Florence, South Carolina 29501 |
Nalitt Cancer Institute at Staten Island University Hospital | Staten Island, New York 10305 |
La Grange Memorial Hospital | La Grange, Illinois 60525 |
Lakes Region General Hospital | Laconia, New Hampshire 03246 |
Roper St. Francis Cancer Center at Roper Hospital | Charleston, South Carolina 29401 |
University of Wisconcin Cancer Center at Aspirus Wausau Hospital | Wausau, Wisconsin 54401 |
Veterans Affairs Medical Center - Iowa City | Iowa City, Iowa 52246-2208 |
Cancer Center at Phoenixville Hospital | Phoenixville, Pennsylvania 19460 |
Doctors Medical Center - San Pablo Campus | San Pablo, California 94806 |
St. Vincent Healthcare Cancer Care Services | Billings, Montana 59101 |
Union Memorial Hospital | Baltimore, Maryland 21218 |
Good Samaritan Hospital of Maryland | Baltimore, Maryland 21239 |
Parvin Radiation Oncology | Kansas City, Missouri 64116 |
East Bay Radiation Oncology Center | Castro Valley, California 94546 |
Contra Costa Regional Medical Center | Martinez, California 94553-3156 |
Memorial Medical Center | Modesto, California 95355 |
El Camino Hospital Cancer Center | Mountain View, California 94040 |
Larry G Strieff MD Medical Corporation | Oakland, California 94609 |
Tom K Lee, Incorporated | Oakland, California 94609 |
Bay Area Breast Surgeons, Incorporated | Oakland, California 94609 |
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline, Illinois 61265 |
Iowa Blood and Cancer Care | Cedar Rapids, Iowa 52402 |
Caritas St. Elizabeth's Medical Center | Brighton, Massachusetts 02135-2997 |
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord, New Hampshire 03301 |
Center for Cancer Care at Exeter Hospital | Exeter, New Hampshire 03833 |
New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett, New Hampshire 03106 |
Trinity CancerCare Center | Minot, North Dakota 58701 |
United States Air Force Medical Center - Wright-Patterson | Wright-Patterson AFB, Ohio 45433-5529 |
Riddle Memorial Hospital Cancer Center | Media, Pennsylvania 19063 |
Cancer Center of Paoli Memorial Hospital | Paoli, Pennsylvania 19301-1792 |
CCOP - Main Line Health | Wynnewood, Pennsylvania 19096 |
AnMed Cancer Center | Anderson, South Carolina 29621 |
Franciscan Skemp Healthcare - La Crosse Campus | La Crosse, Wisconsin 54601 |
Fountain Valley, California 92708 | |
Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg, Pennsylvania 18301 |
Medcenter One Hospital Cancer Care Center | Bismarck, North Dakota 58501 |
St. Alexius Medical Center Cancer Center | Bismarck, North Dakota 58502 |
Cleveland Clinic Florida - Weston | Weston, Florida 33331 |
Suniti Medical Corporation | Merrillville, Indiana 46410 |
St. Mary's Regional Cancer Center at St. Mary's Medical Center | Huntington, West Virginia 25702 |
Providence Cancer Center at PMCC | Medford, Oregon 97504 |
Saint Mary's Regional Medical Center | Reno, Nevada 89503 |
Lovelace Medical Center - Downtown | Albuquerque, New Mexico 87102 |
Callahan Cancer Center at Great Plains Regional Medical Center | North Platte, Nebraska 69103 |
Hematology Oncology Associates, PC | Albuquerque, New Mexico 87106 |
Jersey Shore Cancer Center at Jersey Shore University Medical Center | Neptune, New Jersey 07754-0397 |
Valley Medical Oncology Consultants - Castro Valley | Castro Valley, California 94546 |
Valley Medical Oncology | Fremont, California 94538 |
Memorial Hospital Cancer Center - Colorado Springs | Colorado Springs, Colorado 80909 |
Ochsner Health Center - Covington | Covington, Louisiana 70433 |
Addison Gilbert Hospital | Gloucester, Massachusetts 01930 |
Immanuel St. Joseph's | Mankato, Minnesota 56002 |
Skaggs Cancer Center at Skaggs Regional Medical Center | Branson, Missouri 65616 |
Mercy Regional Cancer Center | Janesville, Wisconsin 53547 |
Columbia Saint Mary's Hospital - Ozaukee | Mequon, Wisconsin 53097 |
Columbia-Saint Mary's Cancer Care Center | Milwaukee, Wisconsin 53211 |
Shore Regional Cancer Center at Memorial Hospital - Easton | Easton, Maryland 21601 |
Minnesota Oncology - Maplewood | Maplewood, Minnesota 55109 |
Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota 55422-2900 |
Lakeview Hospital | Stillwater, Minnesota 55082 |
Minnesota Oncology - Woodbury | Woodbury, Minnesota 55125 |
Camino Medical Group - Treatment Center | Mountain View, California 94040 |
Kings County Hospital Center | Brooklyn, New York 11203 |
Cancer Institute at St. Joseph Medical Center | Towson, Maryland 21204 |
Caritas Holy Family Hospital | Methuen, Massachusetts 01844 |
Radiation Oncology Associates - Reno | Reno, Nevada 89509 |
Clarian Arnett Cancer Care | Lafayette, Indiana 47904 |
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital | Cooperstown, New York 13326 |
CCOP - Kansas City | Prairie Village, Kansas 66208 |
Renown Institute for Cancer at Renown Regional Medical Center | Reno, Nevada 89502 |
Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility | Largo, Maryland 20774 |
Kaiser Permanente Medical Center - Fair Oaks | Fairfax, Virginia 22033 |
Tufts Medical Center Cancer Center | Boston, Massachusetts 02111 |
Langlade Memorial Hospital | Antigo, Wisconsin 54409 |
Cancer Center of South Florida Foundation, Incorporated | Lake Worth, Florida 33461 |
Foundation Medical Partners | Nashua, New Hampshire 03060 |
Medical Oncology and Hematology Associates of North Virginia - Fairfax | Fairfax, Virginia 22031 |
Southeast Cancer Center | Cape Girardeau, Missouri 63703 |
Goldschmidt Cancer Center | Jefferson City, Missouri 65109 |
Comprehensive Cancer Care, PC | Saint Louis, Missouri 63141 |
Lakeside Hospital | Omaha, Nebraska 68130 |
Clackamas Radiation Oncology Center | Clackamas, Oregon 97015 |
Providence Newberg Medical Center | Newberg, Oregon 97132 |
Willamette Falls Hospital | Oregon City, Oregon 97045 |
Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids, Wisconsin 54494 |
Littleton Adventist Hospital | Littleton, Colorado 80122 |
Parker Adventist Hospital | Parker, Colorado 80138 |
Roger Maris Cancer Center at MeritCare Hospital | Fargo, North Dakota 58122 |
St. Nicholas Hospital | Sheboygan, Wisconsin 53081 |
Pacific Medical Center | Seattle, Washington 98104 |
Commonwealth Hematology-Oncology, PC - Quincy | Quincy, Massachusetts 02169 |
Overlake Cancer Center at Overlake Hospital Medical Center | Bellevue, Washington 98004 |
Southern Ohio Medical Center Cancer Center | Portsmouth, Ohio 45662 |
Feather River Hospital Cancer Center | Paradise, California 95969 |
Seacoast Cancer Center at Wentworth - Douglass Hospital | Dover, New Hampshire 03820 |
Trinitas Comprehensive Cancer Center at Trinitas Hospital | Elizabeth, New Jersey 07207 |
Doylestown Hospital Cancer Center | Doylestown, Pennsylvania 18901 |
Central Care Cancer Center at Carrie J. Babb Cancer Center | Bolivar, Missouri 65613 |
Providence Regional Cancer Partnership | Everett, Washington 98201 |
Kaiser Permanente at Capitol Hill Medical Center | Washington, District of Columbia 20002 |
Kaiser Permanente at Woodlawn Medical Center | Baltimore, Maryland 21244 |
Kaiser Permanente - Gaithersburg Medical Center | Gaithersburg, Maryland 20879 |
Dickstein Cancer Treatment Center at White Plains Hospital Center | White Plains, New York 10601 |
Carolina Blood and Cancer Care Associates, PA | Lancaster, South Carolina 29720 |
Carolina Blood and Cancer Care | Rock Hill, South Carolina 29732 |
Lexington Medical Center | West Columbia, South Carolina 29169 |
St. Joseph Regional Medical Center | Lewiston, Idaho 83501 |
D.N. Greenwald Center | Mukwonago, Wisconsin 53149 |
Memorial Hospital at Gulfport | Gulfport, Mississippi 39502 |