Phase II Study of Faslodex In Recurrent/Metastatic Endometrial Cancer
OBJECTIVES:
- Compare the probability of clinical response in estrogen receptor (ER)-positive vs
ER-negative patients with recurrent, persistent, or metastatic endometrial cancer
treated with fulvestrant.
- Compare the relationship between response rate and intensity of receptor expression in
patients treated with this drug.
- Determine the frequency and intensity of toxicity of this drug in these patients.
OUTLINE: Patients receive fulvestrant intramuscularly on day 1. Treatment repeats every 28
days for at least 2 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.
Interventional
Masking: Open Label, Primary Purpose: Treatment
Clinical response by RECIST criteria evaluated every 8 weeks
No
Allan Covens, MD
Study Chair
Edmond Odette Cancer Centre at Sunnybrook
United States: Federal Government
CDR0000068339
NCT00006903
August 2004
Name | Location |
---|---|
Mayo Clinic Scottsdale | Scottsdale, Arizona 85259 |
Mayo Clinic - Jacksonville | Jacksonville, Florida 32224 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
MBCCOP - Hawaii | Honolulu, Hawaii 96813 |
University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
Duke Comprehensive Cancer Center | Durham, North Carolina 27710 |
CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
CCOP - Carle Cancer Center | Urbana, Illinois 61801 |
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus | New Britain, Connecticut 06050 |
Case Comprehensive Cancer Center | Cleveland, Ohio 44106-5065 |
Drexel University College of Medicine - Center City Hahnemann Campus | Philadelphia, Pennsylvania 19102 |
Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse, Wisconsin 54601 |
University of Texas Medical Branch | Galveston, Texas 77555-1329 |
CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
Holden Comprehensive Cancer Center at University of Iowa | Iowa City, Iowa 52242-1002 |
UMASS Memorial Cancer Center - University Campus | Worcester, Massachusetts 01605-2982 |
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill, North Carolina 27599-7570 |
Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
Fletcher Allen Health Care - University Health Center Campus | Burlington, Vermont 05401 |
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock, Arkansas 72205 |
Hulston Cancer Center at Cox Medical Center South | Springfield, Missouri 65807 |
St. John's Regional Health Center | Springfield, Missouri 65804 |
Carol G. Simon Cancer Center at Morristown Memorial Hospital | Morristown, New Jersey 07962 |
SUNY Downstate Medical Center | Brooklyn, New York 11203 |
Cancer Care Associates - Midtown Tulsa | Tulsa, Oklahoma 74104 |
Women and Infants Hospital of Rhode Island | Providence, Rhode Island 02905 |
Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina 27157-1096 |
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas, Texas 75390 |
Battle Creek Health System Cancer Care Center | Battle Creek, Michigan 49017 |
Riverside Methodist Hospital Cancer Care | Columbus, Ohio 43214 |
Jonsson Comprehensive Cancer Center at UCLA | Los Angeles, California 90095-1781 |
MBCCOP - Medical College of Georgia Cancer Center | Augusta, Georgia 30912-3730 |
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah, Georgia 31403-3089 |
Indiana University Melvin and Bren Simon Cancer Center | Indianapolis, Indiana 46202-5289 |
University of Mississippi Cancer Clinic | Jackson, Mississippi 39216-4505 |
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick, New Jersey 08903 |
Oklahoma University Cancer Institute | Oklahoma City, Oklahoma 73104 |
M. D. Anderson Cancer Center at University of Texas | Houston, Texas 77030-4009 |
Methodist Estabrook Cancer Center | Omaha, Nebraska 68114-4199 |
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center | Orange, California 92868 |
Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago, Illinois 60611 |
Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach, California 90801 |
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
Hope A Women's Cancer Center | Asheville, North Carolina 28801 |
Mount Carmel Health - West Hospital | Columbus, Ohio 43222 |
Rosenfeld Cancer Center at Abington Memorial Hospital | Abington, Pennsylvania 19001 |
Fox Chase Cancer Center - Philadelphia | Philadelphia, Pennsylvania 19111-2497 |
David L. Rike Cancer Center at Miami Valley Hospital | Dayton, Ohio 45409 |
Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro, North Carolina 27401 |
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
Louisville Oncology at Norton Cancer Institute - Louisville | Louisville, Kentucky 40202 |