A Phase II Trial of Accelerated Radiotherapy Using Weekly Stereotactic Conformal Boosts For Supratentorial Glioblastoma Multiforme
OBJECTIVES:
- Determine the overall and progression-free survival in patients with supratentorial
glioblastoma multiforme treated with accelerated radiotherapy and conformal
stereotactic radiotherapy boost followed by carmustine.
- Determine the short and long-term toxicity of this regimen in these patients.
- Determine the feasibility of this regimen in these patients.
OUTLINE: Patients receive daily accelerated radiotherapy 5 days a week on weeks 1-2. On
weeks 3-6, patients receive accelerated radiotherapy 4 days a week (3 days a week on week 6)
and conformal stereotactic radiotherapy boost once weekly. Patients then receive carmustine
IV over 1-2 hours on days 1-3 every 8 weeks for 6 courses beginning within 1 month after the
completion of radiotherapy.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually thereafter.
PROJECTED ACCRUAL: A total of 76 patients will be accrued for this study within 15 months.
Interventional
Primary Purpose: Treatment
Rupert Schmidt-Ullrich, MD
Study Chair
Massey Cancer Center
United States: Federal Government
CDR0000068264
NCT00006386
March 2001
Name | Location |
---|---|
Akron City Hospital | Akron, Ohio 44304 |
Roswell Park Cancer Institute | Buffalo, New York 14263 |
University of Texas - MD Anderson Cancer Center | Houston, Texas 77030-4009 |
University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan 48109-0752 |
Mayo Clinic Cancer Center | Rochester, Minnesota 55905 |
Jonsson Comprehensive Cancer Center, UCLA | Los Angeles, California 90095-1781 |
University of Colorado Cancer Center | Denver, Colorado 80262 |
H. Lee Moffitt Cancer Center and Research Institute | Tampa, Florida 33612 |
Emory University Hospital - Atlanta | Atlanta, Georgia 30322 |
MBCCOP - Hawaii | Honolulu, Hawaii 96813 |
Albert B. Chandler Medical Center, University of Kentucky | Lexington, Kentucky 40536-0084 |
CCOP - Ann Arbor Regional | Ann Arbor, Michigan 48106 |
Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
Cancer Center of Albany Medical Center | Albany, New York 12208 |
State University of New York Health Science Center at Brooklyn | Brooklyn, New York 11203 |
Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
Ireland Cancer Center | Cleveland, Ohio 44106-5065 |
Arthur G. James Cancer Hospital - Ohio State University | Columbus, Ohio 43210 |
Milton S. Hershey Medical Center | Hershey, Pennsylvania 17033 |
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia, Pennsylvania 19107 |
Fox Chase Cancer Center | Philadelphia, Pennsylvania 19111 |
CCOP - Upstate Carolina | Spartanburg, South Carolina 29303 |
St. Luke's Medical Center | Milwaukee, Wisconsin 53215 |
Sylvester Cancer Center, University of Miami | Miami, Florida 33136 |
MBCCOP - LSU Medical Center | New Orleans, Louisiana 70112 |
Hurley Medical Center | Flint, Michigan 48503 |
East Carolina University School of Medicine | Greenville, North Carolina 27858-4354 |
Vermont Cancer Center | Burlington, Vermont 05401-3498 |
CCOP - Atlanta Regional | Atlanta, Georgia 30342-1701 |
CCOP - Kansas City | Kansas City, Missouri 64131 |
CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska 68131 |
CCOP - Southern Nevada Cancer Research Foundation | Las Vegas, Nevada 89106 |
CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
Sinai Hospital of Baltimore | Baltimore, Maryland 21225 |
Ellis Fischel Cancer Center - Columbia | Columbia, Missouri 65203 |
Norris Cotton Cancer Center | Lebanon, New Hampshire 03756 |
CCOP - North Shore University Hospital | Manhasset, New York 11030 |
CCOP - Southeast Cancer Control Consortium | Winston-Salem, North Carolina 27104-4241 |
Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis, Indiana 46202 |
CCOP - Kalamazoo | Kalamazoo, Michigan 49007-3731 |
CCOP - Metro-Minnesota | Saint Louis Park, Minnesota 55416 |
Veterans Affairs Medical Center - East Orange | East Orange, New Jersey 07018-1095 |
University of Pittsburgh Cancer Institute | Pittsburgh, Pennsylvania 15213 |
Bloomington Hospital | Bloomington, Indiana 47402 |
Geisinger Medical Center | Danville, Pennsylvania 17822-0001 |
Abramson Cancer Center of the University of Pennsylvania | Philadelphia, Pennsylvania 19104-4283 |
Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
MD Anderson Cancer Center Orlando | Orlando, Florida 32806 |
Loyola University Medical Center | Maywood, Illinois 60153 |
CCOP - Ochsner | New Orleans, Louisiana 70121 |
Rapid City Regional Hospital | Rapid City, South Dakota 57709 |
University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham, Alabama 35294-3300 |
Comprehensive Cancer Center at Wake Forest University | Winston-Salem, North Carolina 27157-1082 |
Cancer Center at the University of Virginia | Charlottesville, Virginia 22908 |
Henry Ford Hospital | Detroit, Michigan 48202 |
Marshfield Clinic | Marshfield, Wisconsin 54449 |
Medical College of Wisconsin | Milwaukee, Wisconsin 53226 |
Huntsville Hospital System | Huntsville, Alabama 35801 |
Alabama Oncology, LLC | Montgomery, Alabama 36106-2801 |
Mount Diablo Medical Center | Concord, California 94524-4110 |
California Cancer Center | Fresno, California 93720 |
Saint Agnes Cancer Center | Fresno, California 93720 |
Loma Linda University Medical Center | Loma Linda, California 92354 |
Veterans Affairs Medical Center - Long Beach | Long Beach, California 90822 |
CCOP - Bay Area Tumor Institute | Oakland, California 94609-3305 |
Radiation Oncology Center - Sacramento | Sacramento, California 95816 |
O'Connor Hospital | San Jose, California 95128 |
CCOP - Santa Rosa Memorial Hospital | Santa Rosa, California 95403 |
David Grant Medical Center | Travis Air Force Base, California 94535 |
Memorial Hospital Cancer Center | Colorado Springs, Colorado 80909 |
University of Florida Health Science Center | Gainesville, Florida 32610-0296 |
Health First Holmes Regional Medical Center | Melbourne, Florida 32901 |
Baptist Hospital of Miami | Miami, Florida 33176-2197 |
Florida Radiation Oncology Group | Orange Park, Florida 32073 |
Gulf Coast Cancer Treatment Center | Panama City, Florida 32405-4587 |
Sarasota Radiation and Medical Oncology Center | Sarasota, Florida 34233 |
Medical Center/John B. Amos Community Cancer Center | Columbus, Georgia 31902 |
Northwest Community Hospital | Arlington Heights, Illinois 60005 |
Northwestern Memorial Hospital | Chicago, Illinois 60611 |
Ingalls Memorial Hospital | Harvey, Illinois 60426 |
Lutheran General Cancer Care Center | Park Ridge, Illinois 60068 |
Methodist Medical Center of Illinois | Peoria, Illinois 61636 |
CCOP - Central Illinois | Springfield, Illinois 62526 |
St. John's Medical Center | Anderson, Indiana 46016 |
Ball Memorial Hospital | Muncie, Indiana 47303-3499 |
Wendt Regional Cancer Center of Finley Hospital | Dubuque, Iowa 52001 |
James Graham Brown Cancer Center | Louisville, Kentucky 40202 |
Louisville Radiation Oncology | Louisville, Kentucky 40215 |
Merle M. Mahr Cancer Center | Madisonville, Kentucky 42431 |
Mary Bird Perkins Cancer Center | Baton Rouge, Louisiana 70809 |
Tulane University School of Medicine | New Orleans, Louisiana 70112 |
Maine Medical Center | Portland, Maine 04102 |
Anne Arundel Oncology Center | Annapolis, Maryland 21401 |
Greater Baltimore Medical Center and Cancer Center | Baltimore, Maryland 21204 |
Harbor Hospital Center | Baltimore, Maryland 21225 |
Cape Cod Hospital | Hyannis, Massachusetts 02601 |
Veterans Affairs Medical Center - Boston (Jamaica Plain) | Jamaica Plain, Massachusetts 02130 |
McLaren Regional Cancer Center | Flint, Michigan 48432 |
Marquette General Hospital | Marquette, Michigan 49855 |
Mallinckrodt Institute of Radiology | Saint Louis, Missouri 63110 |
St. Louis University Health Sciences Center | Saint Louis, Missouri 63110-0250 |
Cancer Research for the Ozarks | Springfield, Missouri 65807 |
CCOP - Cancer Research for the Ozarks | Springfield, Missouri 65807 |
CCOP - Montana Cancer Consortium | Billings, Montana 59101 |
Elliot Regional Cancer Center | Manchester, New Hampshire 03103 |
John F. Kennedy Medical Center | Edison, New Jersey 08818 |
Newark Beth Israel Medical Center | Newark, New Jersey 07112 |
Community Medical Center | Toms River, New Jersey 08755 |
St. Francis Medical Center | Trenton, New Jersey 08629 |
New York Methodist Hospital | Brooklyn, New York 11215-3609 |
Champlain Valley Physicians Hospital Medical Center | Plattsburgh, New York 12901 |
Northeast Medical Center | Concord, North Carolina 28025 |
Akron General Medical Center | Akron, Ohio 44302 |
Christ Hospital | Cincinnati, Ohio 45219 |
University Hospitals of Cleveland | Cleveland, Ohio 44106 |
CCOP - Columbus | Columbus, Ohio 43206 |
CCOP - Dayton | Kettering, Ohio 45429 |
CCOP - Columbia River Program | Portland, Oregon 97213 |
Lehigh Valley Hospital | Allentown, Pennsylvania 18103 |
Delaware County Memorial Hospital | Drexel Hill, Pennsylvania 19026 |
Albert Einstein Cancer Center | Philadelphia, Pennsylvania 19141 |
Veterans Affairs Medical Center - Philadelphia | Philadelphia, Pennsylvania 19104 |
Western Pennsylvania Hospital | Pittsburgh, Pennsylvania 15224 |
Mercy Hospital of Pittsburgh | Pittsburgh, Pennsylvania 15219 |
Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
Mercy Hospital Cancer Center - Scranton | Scranton, Pennsylvania 18501 |
Wilkes Barre General Hospital | Wilkes-Barre, Pennsylvania 18764 |
Roger Williams Medical Center/BUSM | Providence, Rhode Island 02908-4735 |
CCOP - Greenville | Greenville, South Carolina 29615 |
Jackson-Madison County General Hospital | Jackson, Tennessee 38301 |
Harrington Cancer Center | Amarillo, Texas 79106 |
University of Texas Medical Branch | Galveston, Texas 77555-1329 |
Joe Arrington Cancer Research and Treatment Center | Lubbock, Texas 79410-1894 |
Bayshore Medical Center | Pasadena, Texas 77504 |
Dixie Regional Medical Center | Saint George, Utah 84770 |
Naval Medical Center, Portsmouth | Portsmouth, Virginia 23708-2197 |
Massey Cancer Center | Richmond, Virginia 23298-0037 |
Virginia Mason Medical Center | Seattle, Washington 98111 |
Deaconess Medical Center | Spokane, Washington 99210-0248 |
Yakima Valley Memorial Hospital | Yakima, Washington 98902 |
St. Vincent Hospital | Green Bay, Wisconsin 54307-3508 |
Gundersen Lutheran Medical Foundation | La Crosse, Wisconsin 54601 |
University of Wisconsin Comprehensive Cancer Center | Madison, Wisconsin 53792 |
Southern Wisconsin Radiotherapy Center | Madison, Wisconsin 53713 |
Community Memorial Hospital | Menomonee Falls, Wisconsin 53051 |
Columbia Hospital | Milwaukee, Wisconsin 53211 |
Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee, Wisconsin 53295 |
CCOP - Northern Indiana CR Consortium | South Bend, Indiana 46601 |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore, Maryland 21231-2410 |
Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay, Wisconsin 54301 |
Cleveland Clinic Taussig Cancer Center | Cleveland, Ohio 44195 |
MBCCOP - Gulf Coast | Mobile, Alabama 36688 |
USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles, California 90033-0804 |
Herbert Irving Comprehensive Cancer Center | New York, New York 10032 |
Regional Cancer Center | Indianapolis, Indiana 46219 |
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse, New York 13217 |
CCOP - Oklahoma | Tulsa, Oklahoma 74136 |
Comprehensive Cancer Institute of Huntsville | Huntsville, Alabama 35801 |
Foundation for Cancer Research and Education | Phoenix, Arizona 85013 |
Veterans Affairs Medical Center - Miami | Miami, Florida 33125 |
Bay Medical Center | Panama City, Florida 32401 |
Tallahassee Memorial Healthcare | Tallahassee, Florida 32308 |
Peninsula Regional Medical Center | Salisbury, Maryland 21801 |
MidMichigan Medical Center - Midland | Midland, Michigan 48670 |
William Beaumont Hospital | Royal Oak, Michigan 48073 |
Nebraska Health System | Omaha, Nebraska 68105-1018 |
Trinitas Hospital - Jersey Street Campus | Elizabeth, New Jersey 07201 |
Monmouth Medical Center | Long Branch, New Jersey 07740-6395 |
South Jersey Regional Cancer Center | Millville, New Jersey 08332 |
Cancer Institute of New Jersey | New Brunswick, New Jersey 08901 |
Atlantic City Medical Center | Pomona, New Jersey 08240 |
Associated Radiologists, P.A. | Warren, New Jersey 07059 |
St. Anthony Hospital | Oklahoma City, Oklahoma 73101 |
St. John Health System | Tulsa, Oklahoma 74104 |
University of Utah Health Sciences Center | Salt Lake City, Utah 84132 |
Schiffler Cancer Center | Wheeling, West Virginia 26003 |
Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore, Maryland 21201-1595 |
James P. Wilmot Cancer Center | Rochester, New York 14642 |
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma 73104 |
City of Hope Comprehensive Cancer Center | Duarte, California 91010 |
UCSF Comprehensive Cancer Center | San Francisco, California 94115 |
University of Tennessee Cancer Institute | Memphis, Tennessee 38103 |
CCOP - Beaumont | Royal Oak, Michigan 48073-6769 |
DCH Cancer Treatment Center | Tuscaloosa, Alabama 35401 |
Sutter Health West Cancer Research Group | Greenbrae, California 94904 |
Huntington Cancer Center | Pasadena, California 91105 |
Robert and Beverly Lewis Family Cancer Care Center | Pomona, California 91767 |
Radiation Medical Group, Incorporated | San Diego, California 92101 |
Saint Mary's Hospital and Medical Center | Grand Junction, Colorado 81502-1628 |
Hospital of St. Raphael | New Haven, Connecticut 06511 |
Regional Radiation Oncology Center at Rome | Rome, Georgia 30165 |
Clarian Health Partners Inc. | Indianapolis, Indiana 46206-1367 |
Central Baptist Hospital | Lexington, Kentucky 40503 |
William Beaumont Hospital - Troy | Troy, Michigan 48098 |
Methodist Hospital Cancer Center - Omaha | Omaha, Nebraska 68114 |
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital | Mount Holly, New Jersey 08060 |
Valley Hospital | Ridgewood, New Jersey 07450 |
Radiation Oncology Associates of Albuquerque | Albuquerque, New Mexico 87109 |
Finger Lakes Radiation Oncology Center | Clifton Springs, New York 14432 |
Vassar Brothers Medical Center | Poughkeepsie, New York 12601 |
Riverhill Radiation Oncology | Yonkers, New York 10701 |
Trinity Cancer Care Center | Minot, North Dakota 58701 |
Barrett Cancer Center | Cincinnati, Ohio 45267-0502 |
CCOP - Toledo Community Hospital | Toledo, Ohio 43623-3456 |
St. Luke's Hospital Cancer Center | Bethlehem, Pennsylvania 18015 |
Mercy Fitzgerald Hospital | Darby, Pennsylvania 19023 |
Pocono Cancer Center | East Stroudsburg, Pennsylvania 18301 |
York Cancer Center | York, Pennsylvania 17403 |
Wilford Hall Medical Center | Lackland Air Force Base, Texas 78236-5300 |
Latter Day Saints Hospital | Salt Lake City, Utah 84143 |
RMH Regional Cancer Center | Harrisonburg, Virginia 22801 |
Bon Secours - St. Mary's Hospital | Richmond, Virginia 23226 |
All Saints Cancer Center | Racine, Wisconsin 53405 |
Waukesha Memorial Hospital Regional Cancer Center | Waukesha, Wisconsin 53188 |
Cancer Center at Lexington Clinic | Lexington, Kentucky 40504 |