Pilot Study: High Risk Breast Cancer Screening Pilot Study
OBJECTIVES:
- Estimate the diagnostic yield and positive predictive value of breast magnetic
resonance imaging (MRI) for the detection of cancer in women who are at greater than
25% lifetime risk for developing breast cancer.
- Compare the diagnostic yield and positive predictive value of MRI with conventional
breast cancer screening (mammography and physical examination) for the detection of
breast cancer in women with a greater than 25% lifetime risk of developing breast
cancer.
OUTLINE: All patients receive a physical exam within 90 days of initial MRI scan. Patients
undergo a two view screening mammogram within 3 months prior to study entry. Patients
undergo an MRI with gadolinium contrast at entry. All lesions identified as suspicious on
physical examination, mammography, or MRI undergo a core needle or excisional biopsy.
PROJECTED ACCRUAL: A total of 200 patients will be accrued for this study within 2 years.
Interventional
Primary Purpose: Screening
Mitchell Schnall, PhD
Study Chair
Abramson Cancer Center of the University of Pennsylvania
United States: Federal Government
CDR0000066851
NCT00003736
June 1999
Name | Location |
---|---|
Roswell Park Cancer Institute | Buffalo, New York 14263 |
University of Colorado Cancer Center | Denver, Colorado 80262 |
Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
University of Pennsylvania Cancer Center | Philadelphia, Pennsylvania 19104 |
Simmons Cancer Center - Dallas | Dallas, Texas 75235-9154 |
University of Washington Medical Center | Seattle, Washington 98195-6043 |
UCSF Cancer Center and Cancer Research Institute | San Francisco, California 94115-0128 |
Porter Adventist Hospital | Denver, Colorado 80210 |
Cancer Center at the University of Virginia | Charlottesville, Virginia 22908 |
Lombardi Cancer Center | Washington, District of Columbia 20007 |
Hartford Hospital | Hartford, Connecticut 06102-5037 |