Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma
Patients are randomized to receive either DOX-SL or the ABV combination. Infusions are given
on day 1 and every 2 weeks for a total of six cycles. Kaposi's sarcoma lesions are evaluated
prior to every cycle, at the end of the last treatment cycle, and 4 weeks following the end
of the last treatment. Patients must agree to have one or more representative KS lesions
biopsied.
Interventional
Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment
United States: Food and Drug Administration
134A
NCT00002318
Name | Location |
---|---|
Saint Luke's - Roosevelt Hosp Ctr | New York, New York 10025 |
Univ of Miami School of Medicine | Miami, Florida 331361013 |
Henry Ford Hosp | Detroit, Michigan 48202 |
Washington Univ | St Louis, Missouri 63108 |
Baylor College of Medicine | Houston, Texas 77030 |
New York Univ Med Ctr | New York, New York 10016 |
San Francisco Veterans Administration Med Ctr | San Francisco, California 94121 |
East Bay AIDS Ctr | Berkeley, California 94705 |
H Lee Moffit Cancer Ctr and Research Institute | Tampa, Florida 33612 |
Saint Vincent's Hosp and Med Ctr | New York, New York 10011 |
Pacific Oaks Med Group | Beverly Hills, California 90211 |
Hematology - Oncology Med Group of San Fernando Valley | Encino, California 91436 |
Dr Becky Miller | Los Angeles, California 90048 |
Apogee Med Group | San Diego, California 92103 |
Kaiser Permanente Med Ctr | San Francisco, California 94115 |
UCSF | San Francisco, California 941430324 |
UCSF - San Francisco Gen Hosp | San Francisco, California 94110 |
Dr Mahmoud Mustafa | Washington, District of Columbia 20037 |
American Med Research Institute | Atlanta, Georgia 30329 |
Infectious Disease Rsch Consortium of GA / SE Clin Resources | Atlanta, Georgia 30345 |
Rush Presbyterian Med College | Chicago, Illinois 60612 |
Illinois Masonic Med Ctr / The Cancer Ctr | Chicago, Illinois 60657 |
Northwestern Med Faculty Foundation | Chicago, Illinois 60611 |
Roswell Park Cancer Institute | Buffalo, New York 14263 |
Graduate Hosp / Tuttleman Cancer Ctr | Philadelphia, Pennsylvania 19146 |
Comprehensive Care Ctr | Dallas, Texas 75235 |